======= HRH3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HRH3
  * **<color #00a2e8>Official Name</color>**: histamine receptor H3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11255|11255]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5N1|Q9Y5N1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HRH3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HRH3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604525|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of serotonin secretion|
|negative regulation of glutamate secretion|
|histamine receptor activity|
|regulation of serotonin secretion|
|G protein-coupled acetylcholine receptor activity|
|adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway|
|negative regulation of amino acid transport|
|regulation of norepinephrine secretion|
|regulation of glutamate secretion|
|G protein-coupled acetylcholine receptor signaling pathway|
|negative regulation of organic acid transport|
|negative regulation of neurotransmitter transport|
|negative regulation of amine transport|
|negative regulation of anion transport|
|acetylcholine receptor signaling pathway|
|regulation of amino acid transport|
|response to acetylcholine|
|cellular response to acetylcholine|
|G protein-coupled serotonin receptor signaling pathway|
|G protein-coupled serotonin receptor activity|
|neurotransmitter receptor activity|
|serotonin receptor signaling pathway|
|postsynaptic signal transduction|
|regulation of organic acid transport|
|regulation of catecholamine secretion|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|cellular response to dopamine|
|response to dopamine|
|signal transduction involved in cellular response to ammonium ion|
|regulation of amine transport|
|presynapse|
|regulation of anion transport|
|neurotransmitter secretion|
|signal release from synapse|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|response to catecholamine|
|response to monoamine|
|cellular response to ammonium ion|
|regulation of neurotransmitter transport|
|negative regulation of ion transport|
|signal release|
|neurotransmitter transport|
|response to ammonium ion|
|negative regulation of secretion by cell|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|negative regulation of secretion|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|cognition|
|regulation of neurotransmitter levels|
|cellular response to drug|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|synaptic signaling|
|negative regulation of transport|
|cellular response to organic cyclic compound|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|regulation of ion transport|
|G protein-coupled receptor activity|
|regulation of secretion by cell|
|regulation of secretion|
|response to hormone|
|response to organic cyclic compound|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|export from cell|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell-cell signaling|
|secretion|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|establishment of localization in cell|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9544
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HRH3 Expression in NALM6 Cells: -5.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>