======= HSD11B2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSD11B2
  * **<color #00a2e8>Official Name</color>**: hydroxysteroid 11-beta dehydrogenase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3291|3291]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P80365|P80365]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSD11B2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSD11B2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614232|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|adh short|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity|
|regulation of blood volume by renal aldosterone|
|glucocorticoid biosynthetic process|
|positive regulation of systemic arterial blood pressure|
|renal system process involved in regulation of blood volume|
|glucocorticoid metabolic process|
|response to food|
|renal system process involved in regulation of systemic arterial blood pressure|
|steroid binding|
|positive regulation of blood pressure|
|regulation of systemic arterial blood pressure by hormone|
|NAD binding|
|steroid hormone biosynthetic process|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|hormone biosynthetic process|
|regulation of systemic arterial blood pressure|
|renal system process|
|steroid biosynthetic process|
|response to glucocorticoid|
|response to corticosteroid|
|female pregnancy|
|regulation of blood pressure|
|hormone metabolic process|
|multi-multicellular organism process|
|response to insulin|
|steroid metabolic process|
|response to steroid hormone|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|response to peptide|
|regulation of body fluid levels|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of hormone levels|
|lipid biosynthetic process|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|oxidation-reduction process|
|multi-organism reproductive process|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|response to abiotic stimulus|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9408
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSD11B2 Expression in NALM6 Cells: -3.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>