======= HSD17B12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSD17B12
  * **<color #00a2e8>Official Name</color>**: hydroxysteroid 17-beta dehydrogenase 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51144|51144]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53GQ0|Q53GQ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSD17B12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSD17B12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609574|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the second of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3- ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:16166196}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|adh short|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-oxo-arachidoyl-CoA reductase activity|
|3-oxo-cerotoyl-CoA reductase activity|
|3-oxo-lignoceroyl-CoA reductase activity|
|3-oxo-behenoyl-CoA reductase activity|
|estradiol 17-beta-dehydrogenase activity|
|estrogen biosynthetic process|
|long-chain fatty-acyl-CoA biosynthetic process|
|long-chain fatty-acyl-CoA metabolic process|
|fibronectin binding|
|estrogen metabolic process|
|fatty-acyl-CoA biosynthetic process|
|fatty-acyl-CoA metabolic process|
|thioester biosynthetic process|
|acyl-CoA biosynthetic process|
|steroid hormone biosynthetic process|
|ribonucleoside bisphosphate biosynthetic process|
|purine nucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|hormone biosynthetic process|
|collagen binding|
|fatty acid derivative biosynthetic process|
|thioester metabolic process|
|acyl-CoA metabolic process|
|fatty acid biosynthetic process|
|cellular hormone metabolic process|
|positive regulation of cell-substrate adhesion|
|steroid biosynthetic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|coenzyme biosynthetic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|fatty acid derivative metabolic process|
|ribose phosphate biosynthetic process|
|heparin binding|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|hormone metabolic process|
|regulation of cell-substrate adhesion|
|cofactor biosynthetic process|
|extracellular matrix|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|steroid metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|purine ribonucleotide metabolic process|
|fatty acid metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|extracellular matrix organization|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|extracellular structure organization|
|positive regulation of cell adhesion|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|regulation of cell adhesion|
|cellular amide metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp483|FTY720 3μM R08 exp483]]|-3.34|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.78|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.65|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.55|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.24|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.21|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-2.19|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-2.08|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.99|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.79|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.72|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.73|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.82|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.84|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.93|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.05|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.13|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.2|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.2|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.5|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.52|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.59|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.69|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.76|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|3.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:agpat1|AGPAT1]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 110/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|1/28|
|blood|5/28|
|bone|0/26|
|breast|4/33|
|central nervous system|14/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|1/16|
|kidney|5/21|
|liver|7/20|
|lung|11/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|3/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|6/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2198
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSD17B12 Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>