======= HSP90AA1 =======
== Gene Information ==
* **Official Symbol**: HSP90AA1
* **Official Name**: heat shock protein 90 alpha family class A member 1
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3320|3320]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P07900|P07900]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=HSP90AA1&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSP90AA1|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/140571|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: N/A
* **UniProt Summary**: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1- mediated inhibition of TGF-beta signaling via inhibition of STUB1- mediated SMAD3 ubiquitination and degradation (PubMed:24613385). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27353360, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.
|HATPase c|
|HSP90|
|protein unfolding|
|telomerase holoenzyme complex assembly|
|protein insertion into mitochondrial outer membrane|
|positive regulation of tau-protein kinase activity|
|outer mitochondrial membrane organization|
|nitric-oxide synthase regulator activity|
|TPR domain binding|
|chaperone-mediated autophagy|
|dendritic growth cone|
|regulation of tau-protein kinase activity|
|endocytic vesicle lumen|
|establishment of protein localization to mitochondrial membrane|
|MHC class II protein complex binding|
|chaperone-mediated protein complex assembly|
|DNA polymerase binding|
|protein insertion into mitochondrial membrane|
|ATPase activity, coupled|
|telomere maintenance via telomerase|
|protein tyrosine kinase binding|
|axonal growth cone|
|telomere maintenance via telomere lengthening|
|myelin sheath|
|ERBB2 signaling pathway|
|disordered domain specific binding|
|GTPase binding|
|axon extension|
|central nervous system neuron axonogenesis|
|RNA-dependent DNA biosynthetic process|
|positive regulation of telomerase activity|
|protein refolding|
|protein insertion into membrane|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|regulation of nitric-oxide synthase activity|
|tau protein binding|
|response to cold|
|positive regulation of reactive oxygen species biosynthetic process|
|regulation of telomerase activity|
|regulation of monooxygenase activity|
|regulation of nitric oxide biosynthetic process|
|protein targeting to mitochondrion|
|scaffold protein binding|
|neuron projection extension|
|nucleotide binding|
|positive regulation of DNA biosynthetic process|
|vascular endothelial growth factor receptor signaling pathway|
|cellular response to heat|
|ERBB signaling pathway|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|regulation of cellular response to heat|
|central nervous system neuron development|
|regulation of reactive oxygen species biosynthetic process|
|developmental cell growth|
|cell growth|
|lysosomal lumen|
|regulation of oxidoreductase activity|
|ciliary basal body-plasma membrane docking|
|positive regulation of reactive oxygen species metabolic process|
|telomere maintenance|
|melanosome|
|telomere organization|
|positive regulation of peptidyl-serine phosphorylation|
|response to heat|
|DNA biosynthetic process|
|histone deacetylase binding|
|regulation of DNA biosynthetic process|
|developmental growth involved in morphogenesis|
|secretory granule lumen|
|establishment of cell polarity|
|ficolin-1-rich granule lumen|
|positive regulation of protein polymerization|
|mitochondrial membrane organization|
|G2/M transition of mitotic cell cycle|
|unfolded protein binding|
|cell cycle G2/M phase transition|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|regulation of peptidyl-serine phosphorylation|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|positive regulation of cellular protein catabolic process|
|protein import|
|response to unfolded protein|
|positive regulation of protein kinase B signaling|
|organelle localization by membrane tethering|
|response to temperature stimulus|
|protein stabilization|
|regulation of reactive oxygen species metabolic process|
|membrane docking|
|central nervous system neuron differentiation|
|response to topologically incorrect protein|
|positive regulation of DNA metabolic process|
|regulation of G2/M transition of mitotic cell cycle|
|establishment or maintenance of cell polarity|
|regulation of protein ubiquitination|
|regulation of cell cycle G2/M phase transition|
|mitochondrial transport|
|positive regulation of protein catabolic process|
|regulation of protein kinase B signaling|
|regulation of protein polymerization|
|regulation of protein modification by small protein conjugation or removal|
|protein folding|
|ribonucleoprotein complex assembly|
|ATPase activity|
|receptor-mediated endocytosis|
|Fc receptor signaling pathway|
|ribonucleoprotein complex subunit organization|
|positive regulation of protein complex assembly|
|regulation of cellular protein catabolic process|
|autophagy|
|process utilizing autophagic mechanism|
|establishment of protein localization to membrane|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|response to antibiotic|
|phagocytosis|
|anatomical structure homeostasis|
|cilium assembly|
|regulation of neurotransmitter levels|
|regulation of DNA metabolic process|
|protein targeting|
|positive regulation of cellular catabolic process|
|cilium organization|
|axonogenesis|
|neuronal cell body|
|regulation of protein catabolic process|
|developmental growth|
|growth|
|axon development|
|regulation of mitotic cell cycle phase transition|
|establishment of protein localization to organelle|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of catabolic process|
|cofactor metabolic process|
|mitochondrion organization|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|ribonucleoprotein complex biogenesis|
|cell projection assembly|
|protein localization to membrane|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|neutrophil degranulation|
|cell projection morphogenesis|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|leukocyte degranulation|
|cell part morphogenesis|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|myeloid cell activation involved in immune response|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|endocytosis|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|organelle localization|
|myeloid leukocyte activation|
|protein-containing complex|
|immune response-regulating signaling pathway|
|mitotic cell cycle process|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of mitotic cell cycle|
|activation of immune response|
|positive regulation of transferase activity|
|neuron projection development|
|cytokine-mediated signaling pathway|
|import into cell|
|mitotic cell cycle|
|protein catabolic process|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of cellular response to stress|
|protein localization to organelle|
|DNA metabolic process|
|regulation of cell cycle process|
|organelle assembly|
|leukocyte mediated immunity|
|exocytosis|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|membrane organization|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|regulation of cellular localization|
|leukocyte activation|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|central nervous system development|
|regulation of catabolic process|
|intracellular protein transport|
|cell cycle process|
|secretion by cell|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|chromosome organization|
|identical protein binding|
|cell activation|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|cell cycle|
|RNA binding|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-3.46|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.75|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.72|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.72|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.76|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.84|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.85|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.96|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.24|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.29|
|[[:results:exp539|42°C R08 exp539]]|2.38|
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 12238
* **Expression level (log2 read counts)**: 11.45
{{:chemogenomics:nalm6 dist.png?nolink |}}