======= HSP90AB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSP90AB1
  * **<color #00a2e8>Official Name</color>**: heat shock protein 90 alpha family class B member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3326|3326]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08238|P08238]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSP90AB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSP90AB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/140572|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co- chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone that is involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HATPase c|
|HSP90|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CTP binding|
|ooplasm|
|negative regulation of transforming growth factor beta activation|
|sulfonylurea receptor binding|
|aryl hydrocarbon receptor complex|
|UTP binding|
|HSP90-CDC37 chaperone complex|
|sperm head plasma membrane|
|negative regulation of complement-dependent cytotoxicity|
|dATP binding|
|telomerase holoenzyme complex assembly|
|histone methyltransferase binding|
|positive regulation of tau-protein kinase activity|
|nitric-oxide synthase regulator activity|
|regulation of transforming growth factor beta activation|
|TPR domain binding|
|ATP-dependent protein binding|
|dendritic growth cone|
|negative regulation of transforming growth factor beta production|
|virion attachment to host cell|
|protein kinase regulator activity|
|regulation of tau-protein kinase activity|
|regulation of complement-dependent cytotoxicity|
|adhesion of symbiont to host cell|
|positive regulation of cell size|
|adhesion of symbiont to host|
|MHC class II protein complex binding|
|positive regulation of protein localization to cell surface|
|chaperone-mediated protein complex assembly|
|DNA polymerase binding|
|inclusion body|
|ATPase activity, coupled|
|positive regulation of phosphoprotein phosphatase activity|
|telomere maintenance via telomerase|
|negative regulation of cell killing|
|negative regulation of cell cycle arrest|
|response to salt stress|
|regulation of interferon-gamma-mediated signaling pathway|
|regulation of response to interferon-gamma|
|axonal growth cone|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|cellular response to interleukin-4|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|telomere maintenance via telomere lengthening|
|response to interleukin-4|
|disordered domain specific binding|
|regulation of type I interferon-mediated signaling pathway|
|positive regulation of phosphatase activity|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|RNA-dependent DNA biosynthetic process|
|positive regulation of cyclin-dependent protein kinase activity|
|central nervous system neuron axonogenesis|
|axon extension|
|regulation of transforming growth factor beta production|
|COP9 signalosome|
|positive regulation of telomerase activity|
|regulation of protein localization to cell surface|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|positive regulation of protein dephosphorylation|
|tau protein binding|
|negative regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of reactive oxygen species biosynthetic process|
|regulation of telomerase activity|
|peptide binding|
|brush border membrane|
|response to cocaine|
|regulation of nitric oxide biosynthetic process|
|negative regulation of proteasomal protein catabolic process|
|heat shock protein binding|
|positive regulation of dephosphorylation|
|neuron projection extension|
|positive regulation of DNA biosynthetic process|
|double-stranded RNA binding|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|response to osmotic stress|
|response to anesthetic|
|regulation of cellular response to heat|
|central nervous system neuron development|
|regulation of reactive oxygen species biosynthetic process|
|negative regulation of cellular protein catabolic process|
|developmental cell growth|
|cell growth|
|kinase binding|
|positive regulation of protein binding|
|positive regulation of reactive oxygen species metabolic process|
|telomere maintenance|
|regulation of cell killing|
|melanosome|
|telomere organization|
|regulation of cyclin-dependent protein kinase activity|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of cell cycle arrest|
|DNA biosynthetic process|
|histone deacetylase binding|
|regulation of DNA biosynthetic process|
|response to alkaloid|
|regulation of transforming growth factor beta receptor signaling pathway|
|developmental growth involved in morphogenesis|
|secretory granule lumen|
|regulation of cellular response to transforming growth factor beta stimulus|
|establishment of cell polarity|
|regulation of phosphoprotein phosphatase activity|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|ficolin-1-rich granule lumen|
|ion channel binding|
|xenobiotic metabolic process|
|unfolded protein binding|
|negative regulation of protein catabolic process|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|regulation of peptidyl-serine phosphorylation|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|regulation of protein dephosphorylation|
|negative regulation of neuron apoptotic process|
|placenta development|
|regulation of ubiquitin-dependent protein catabolic process|
|protein dimerization activity|
|response to unfolded protein|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of protein kinase B signaling|
|regulation of response to cytokine stimulus|
|regulation of phosphatase activity|
|positive regulation of binding|
|protein stabilization|
|central nervous system neuron differentiation|
|regulation of reactive oxygen species metabolic process|
|regulation of cell size|
|regulation of proteasomal protein catabolic process|
|response to ammonium ion|
|cellular response to xenobiotic stimulus|
|response to topologically incorrect protein|
|positive regulation of DNA metabolic process|
|establishment or maintenance of cell polarity|
|basolateral plasma membrane|
|regulation of protein ubiquitination|
|viral life cycle|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|regulation of dephosphorylation|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein binding|
|regulation of protein kinase B signaling|
|regulation of protein modification by small protein conjugation or removal|
|protein folding|
|ribonucleoprotein complex assembly|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|Fc receptor signaling pathway|
|ribonucleoprotein complex subunit organization|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cytokine production|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|lysosomal membrane|
|response to xenobiotic stimulus|
|negative regulation of catabolic process|
|cadherin binding|
|regulation of neuron death|
|apical plasma membrane|
|positive regulation of cellular protein localization|
|negative regulation of cell cycle process|
|phagocytosis|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|negative regulation of proteolysis|
|regulation of neurotransmitter levels|
|regulation of DNA metabolic process|
|neuronal cell body|
|axonogenesis|
|regulation of binding|
|positive regulation of cell cycle|
|regulation of cellular component size|
|regulation of protein catabolic process|
|developmental growth|
|GTP binding|
|growth|
|cellular response to drug|
|axon development|
|reproductive structure development|
|reproductive system development|
|cell morphogenesis involved in neuron differentiation|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|ribonucleoprotein complex biogenesis|
|supramolecular fiber organization|
|protein kinase binding|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|neutrophil degranulation|
|cell projection morphogenesis|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|cell part morphogenesis|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|protein-containing complex|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|positive regulation of transferase activity|
|neuron projection development|
|developmental process involved in reproduction|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|viral process|
|regulated exocytosis|
|cell morphogenesis|
|regulation of proteolysis|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|regulation of defense response|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|symbiotic process|
|exocytosis|
|regulation of protein kinase activity|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|response to organic cyclic compound|
|leukocyte activation|
|biological adhesion|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|negative regulation of cell death|
|regulation of catabolic process|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|export from cell|
|positive regulation of phosphorylation|
|chromosome organization|
|identical protein binding|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|secretion|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|mitochondrion|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|RNA binding|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-2.56|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.53|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.51|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.37|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.79|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.78|
|[[:results:exp539|42°C R08 exp539]]|1.7|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.76|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.97|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2299
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 11.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSP90AB1 Expression in NALM6 Cells: 11.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>