======= HSPA1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSPA1L
  * **<color #00a2e8>Official Name</color>**: heat shock protein family A (Hsp70) member 1 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3305|3305]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P34931|P34931]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSPA1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSPA1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/140559|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HSP70|
|MreB Mbl|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|zona pellucida receptor complex|
|ATPase activity, coupled|
|protein folding chaperone|
|misfolded protein binding|
|positive regulation of protein targeting to mitochondrion|
|chaperone cofactor-dependent protein refolding|
|binding of sperm to zona pellucida|
|COP9 signalosome|
|protein refolding|
|de novo posttranslational protein folding|
|de novo protein folding|
|regulation of protein targeting to mitochondrion|
|sperm-egg recognition|
|heat shock protein binding|
|chaperone-mediated protein folding|
|positive regulation of establishment of protein localization to mitochondrion|
|cellular response to heat|
|cell-cell recognition|
|cell body|
|regulation of establishment of protein localization to mitochondrion|
|regulation of cellular response to heat|
|regulation of protein targeting|
|response to heat|
|positive regulation of mitochondrion organization|
|cellular response to unfolded protein|
|unfolded protein binding|
|single fertilization|
|blood microparticle|
|cellular response to topologically incorrect protein|
|positive regulation of intracellular protein transport|
|response to unfolded protein|
|fertilization|
|response to temperature stimulus|
|regulation of mitochondrion organization|
|response to topologically incorrect protein|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|protein folding|
|ATPase activity|
|cell recognition|
|ubiquitin protein ligase binding|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|mitochondrial matrix|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|sexual reproduction|
|regulation of cellular localization|
|positive regulation of transport|
|multi-organism reproductive process|
|regulation of protein localization|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|reproductive process|
|reproduction|
|regulation of response to stress|
|ATP binding|
|cellular response to stress|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.85|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.75|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15868
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSPA1L Expression in NALM6 Cells: -0.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>