======= HSPA4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSPA4
  * **<color #00a2e8>Official Name</color>**: heat shock protein family A (Hsp70) member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3308|3308]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P34932|P34932]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSPA4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSPA4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601113|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HSP70|
|MreB Mbl|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein insertion into mitochondrial outer membrane|
|outer mitochondrial membrane organization|
|establishment of protein localization to mitochondrial membrane|
|chaperone-mediated protein complex assembly|
|protein insertion into mitochondrial membrane|
|protein insertion into membrane|
|protein targeting to mitochondrion|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial membrane organization|
|protein import|
|response to unfolded protein|
|response to topologically incorrect protein|
|mitochondrial transport|
|establishment of protein localization to membrane|
|protein targeting|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to membrane|
|protein localization to organelle|
|cellular protein-containing complex assembly|
|membrane organization|
|intracellular protein transport|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.87|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.8|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.65|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.62|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.5|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-2.43|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.23|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.21|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-2.15|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.08|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-2.05|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.97|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.93|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.93|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.87|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.84|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.83|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.8|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.8|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.78|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.74|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.74|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.71|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.71|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.7|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.7|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.73|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.76|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.76|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.86|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.95|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.96|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.13|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.45|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.52|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.55|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.14|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|3.79|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|3.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cep120|CEP120]]|0.443|
|[[:human genes:c:c14orf80|C14orf80]]|0.427|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11694
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSPA4 Expression in NALM6 Cells: 7.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>