======= HSPA9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSPA9
  * **<color #00a2e8>Official Name</color>**: heat shock protein family A (Hsp70) member 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3313|3313]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P38646|P38646]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSPA9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSPA9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600548|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGGY C|
|HSP70|
|MreB Mbl|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of hematopoietic stem cell differentiation|
|negative regulation of hematopoietic progenitor cell differentiation|
|negative regulation of erythrocyte differentiation|
|metallo-sulfur cluster assembly|
|iron-sulfur cluster assembly|
|ATPase activity, coupled|
|negative regulation of stem cell differentiation|
|protein folding chaperone|
|misfolded protein binding|
|chaperone cofactor-dependent protein refolding|
|de novo posttranslational protein folding|
|protein refolding|
|de novo protein folding|
|mitochondrial nucleoid|
|regulation of erythrocyte differentiation|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|response to interleukin-12|
|heat shock protein binding|
|chaperone-mediated protein folding|
|cellular response to heat|
|regulation of hematopoietic stem cell differentiation|
|negative regulation of myeloid cell differentiation|
|erythrocyte differentiation|
|regulation of hematopoietic progenitor cell differentiation|
|erythrocyte homeostasis|
|myeloid cell homeostasis|
|response to heat|
|regulation of stem cell differentiation|
|cellular response to unfolded protein|
|unfolded protein binding|
|negative regulation of hemopoiesis|
|cellular response to topologically incorrect protein|
|protein export from nucleus|
|nuclear export|
|response to unfolded protein|
|response to temperature stimulus|
|response to topologically incorrect protein|
|homeostasis of number of cells|
|cofactor biosynthetic process|
|myeloid cell differentiation|
|regulation of myeloid cell differentiation|
|protein folding|
|ATPase activity|
|nucleocytoplasmic transport|
|nuclear transport|
|ubiquitin protein ligase binding|
|sulfur compound metabolic process|
|mitochondrial matrix|
|focal adhesion|
|cofactor metabolic process|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|cytokine-mediated signaling pathway|
|negative regulation of cell differentiation|
|nucleolus|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of developmental process|
|negative regulation of cell death|
|intracellular protein transport|
|cellular response to cytokine stimulus|
|response to cytokine|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|mitochondrion|
|RNA binding|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-2.28|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.13|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.95|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.8|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.71|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.72|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.75|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.75|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.8|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.8|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|1.92|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.09|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.13|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.547|
|[[:human genes:a:alas2|ALAS2]]|0.44|
|[[:human genes:u:uba3|UBA3]]|0.434|
|[[:human genes:r:rptor|RPTOR]]|0.432|
|[[:human genes:p:psmb11|PSMB11]]|0.431|
|[[:human genes:t:timm23b|TIMM23B]]|0.43|
|[[:human genes:m:meaf6|MEAF6]]|0.426|
|[[:human genes:c:ccdc101|CCDC101]]|0.426|
|[[:human genes:c:cars|CARS]]|0.416|
|[[:human genes:n:nbn|NBN]]|0.411|
|[[:human genes:t:tti1|TTI1]]|0.408|
|[[:human genes:p:pam16|PAM16]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 737/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 519
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSPA9 Expression in NALM6 Cells: 8.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>