======= HTR1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HTR1A
  * **<color #00a2e8>Official Name</color>**: 5-hydroxytryptamine receptor 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3350|3350]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08908|P08908]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HTR1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HTR1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8138923, ECO:0000269|PubMed:8393041}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenylate cyclase-inhibiting serotonin receptor signaling pathway|
|receptor-receptor interaction|
|regulation of serotonin secretion|
|serotonin metabolic process|
|serotonin binding|
|primary amino compound metabolic process|
|regulation of catecholamine metabolic process|
|regulation of dopamine metabolic process|
|indole-containing compound metabolic process|
|exploration behavior|
|behavioral fear response|
|vasoconstriction|
|behavioral defense response|
|fear response|
|G protein-coupled serotonin receptor activity|
|G protein-coupled serotonin receptor signaling pathway|
|neurotransmitter receptor activity|
|negative regulation of blood vessel diameter|
|serotonin receptor signaling pathway|
|multicellular organismal response to stress|
|regulation of behavior|
|regulation of cellular amine metabolic process|
|phenol-containing compound metabolic process|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|cellular response to dopamine|
|response to dopamine|
|neurotransmitter metabolic process|
|signal transduction involved in cellular response to ammonium ion|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|response to monoamine|
|response to catecholamine|
|cellular response to ammonium ion|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|regulation of neurotransmitter transport|
|vascular process in circulatory system|
|response to ammonium ion|
|ammonium ion metabolic process|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of hormone secretion|
|regulation of neurotransmitter levels|
|blood circulation|
|circulatory system process|
|cellular response to drug|
|anterograde trans-synaptic signaling|
|dendrite|
|chemical synaptic transmission|
|trans-synaptic signaling|
|organic hydroxy compound metabolic process|
|synaptic signaling|
|regulation of anatomical structure size|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|cell population proliferation|
|behavior|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|regulation of ion transport|
|G protein-coupled receptor activity|
|regulation of secretion by cell|
|regulation of secretion|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|defense response|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4290
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HTR1A Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>