======= HTRA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HTRA2
  * **<color #00a2e8>Official Name</color>**: HtrA serine peptidase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27429|27429]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43464|O43464]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HTRA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HTRA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606441|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. {ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
|Trypsin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pentacyclic triterpenoid metabolic process|
|negative regulation of mitophagy in response to mitochondrial depolarization|
|serine-type endopeptidase complex|
|triterpenoid metabolic process|
|negative regulation of mitophagy|
|negative regulation of autophagy of mitochondrion|
|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|CD40 receptor complex|
|regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|response to herbicide|
|protein autoprocessing|
|regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|regulation of mitophagy|
|response to mitochondrial depolarisation|
|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|cellular response to interferon-beta|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|response to interferon-beta|
|adult walking behavior|
|walking behavior|
|protein homotrimerization|
|positive regulation of protein targeting to mitochondrion|
|negative regulation of macroautophagy|
|regulation of autophagy of mitochondrion|
|regulation of protein targeting to mitochondrion|
|negative regulation of cellular response to oxidative stress|
|negative regulation of oxidative stress-induced cell death|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of response to oxidative stress|
|positive regulation of extrinsic apoptotic signaling pathway|
|execution phase of apoptosis|
|negative regulation of mitochondrion organization|
|cytoplasmic side of plasma membrane|
|protein trimerization|
|positive regulation of establishment of protein localization to mitochondrion|
|serine-type peptidase activity|
|regulation of oxidative stress-induced cell death|
|regulation of multicellular organism growth|
|cellular response to retinoic acid|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|cellular response to heat|
|regulation of establishment of protein localization to mitochondrion|
|regulation of cellular response to oxidative stress|
|mitochondrial intermembrane space|
|adult locomotory behavior|
|peptidase activity|
|regulation of protein targeting|
|negative regulation of autophagy|
|ceramide metabolic process|
|regulation of response to oxidative stress|
|negative regulation of intrinsic apoptotic signaling pathway|
|mitochondrial membrane|
|response to retinoic acid|
|response to heat|
|chromatin|
|positive regulation of mitochondrion organization|
|terpenoid metabolic process|
|unfolded protein binding|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|isoprenoid metabolic process|
|adult behavior|
|intrinsic apoptotic signaling pathway|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of intracellular protein transport|
|regulation of extrinsic apoptotic signaling pathway|
|sphingolipid metabolic process|
|protein processing|
|regulation of intrinsic apoptotic signaling pathway|
|serine-type endopeptidase activity|
|regulation of macroautophagy|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|response to temperature stimulus|
|regulation of mitochondrion organization|
|positive regulation of peptidase activity|
|locomotory behavior|
|membrane lipid metabolic process|
|negative regulation of neuron death|
|positive regulation of intracellular transport|
|cellular response to acid chemical|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|protein maturation|
|negative regulation of apoptotic signaling pathway|
|regulation of intracellular protein transport|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of cellular catabolic process|
|aging|
|apoptotic signaling pathway|
|negative regulation of catabolic process|
|regulation of neuron death|
|positive regulation of cellular protein localization|
|regulation of developmental growth|
|regulation of autophagy|
|protein homooligomerization|
|response to acid chemical|
|regulation of intracellular transport|
|positive regulation of proteolysis|
|cytoskeleton|
|negative regulation of organelle organization|
|forebrain development|
|response to oxidative stress|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|mitochondrion organization|
|regulation of peptidase activity|
|positive regulation of establishment of protein localization|
|cellular response to growth factor stimulus|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|protein complex oligomerization|
|cellular response to lipid|
|response to growth factor|
|regulation of cellular protein localization|
|behavior|
|negative regulation of cell cycle|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of growth|
|protein catabolic process|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|head development|
|cellular amide metabolic process|
|neuron development|
|regulation of cellular catabolic process|
|response to lipid|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|apoptotic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|central nervous system development|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|neuron differentiation|
|regulation of protein localization|
|macromolecule catabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|identical protein binding|
|cell death|
|response to cytokine|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|lipid metabolic process|
|mitochondrion|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.73|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.7|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.7|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.73|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.75|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.76|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.76|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.77|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.77|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.79|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.8|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.81|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.81|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.82|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.85|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.88|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.89|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.93|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.96|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.97|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.02|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.11|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.18|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.21|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.35|
|[[:results:exp453|B02 10μM R08 exp453]]|2.53|
|[[:results:exp539|42°C R08 exp539]]|4.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6436
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HTRA2 Expression in NALM6 Cells: 5.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>