======= HYAL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HYAL1
  * **<color #00a2e8>Official Name</color>**: hyaluronidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3373|3373]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12794|Q12794]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HYAL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HYAL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607071|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco hydro 56|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hyaluranon cable|
|positive regulation of hyaluranon cable assembly|
|regulation of hyaluranon cable assembly|
|hyaluronan synthase activity|
|hyaluronan biosynthetic process|
|hyalurononglucosaminidase activity|
|cellular response to UV-B|
|embryonic skeletal joint morphogenesis|
|chondroitin sulfate catabolic process|
|embryonic skeletal joint development|
|hyaluronan catabolic process|
|response to UV-B|
|cellular response to platelet-derived growth factor stimulus|
|response to platelet-derived growth factor|
|cellular response to pH|
|hyaluronan metabolic process|
|positive regulation of G1/S transition of mitotic cell cycle|
|chondroitin sulfate metabolic process|
|response to pH|
|chondroitin sulfate proteoglycan metabolic process|
|positive regulation of cell cycle G1/S phase transition|
|sulfur compound catabolic process|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|virus receptor activity|
|positive regulation of mitotic cell cycle phase transition|
|cellular response to UV|
|proteoglycan metabolic process|
|lysosomal lumen|
|embryonic skeletal system morphogenesis|
|positive regulation of cell cycle phase transition|
|viral entry into host cell|
|entry into host|
|entry into host cell|
|glycosaminoglycan biosynthetic process|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|cellular response to fibroblast growth factor stimulus|
|cellular response to light stimulus|
|response to fibroblast growth factor|
|embryonic skeletal system development|
|positive regulation of epithelial cell migration|
|response to UV|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|glycosaminoglycan metabolic process|
|interaction with host|
|positive regulation of cell growth|
|positive regulation of angiogenesis|
|regulation of cell cycle G1/S phase transition|
|aminoglycan metabolic process|
|cartilage development|
|cellular response to interleukin-1|
|cellular response to radiation|
|positive regulation of vasculature development|
|negative regulation of cell growth|
|positive regulation of epithelial cell proliferation|
|carbohydrate derivative catabolic process|
|response to reactive oxygen species|
|response to interleukin-1|
|viral life cycle|
|regulation of epithelial cell migration|
|connective tissue development|
|skeletal system morphogenesis|
|cellular response to tumor necrosis factor|
|negative regulation of growth|
|lysosome|
|cytoplasmic vesicle|
|positive regulation of growth|
|response to tumor necrosis factor|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|response to virus|
|positive regulation of cell cycle process|
|regulation of angiogenesis|
|embryonic organ morphogenesis|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|response to antibiotic|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of vasculature development|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|sulfur compound metabolic process|
|positive regulation of cell cycle|
|glycoprotein metabolic process|
|response to oxidative stress|
|positive regulation of cell adhesion|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|embryonic organ development|
|small molecule catabolic process|
|response to radiation|
|regulation of cell cycle phase transition|
|carbohydrate metabolic process|
|skeletal system development|
|inflammatory response|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|embryonic morphogenesis|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of growth|
|regulation of cell adhesion|
|viral process|
|regulation of cell cycle process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cell migration|
|carboxylic acid metabolic process|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|response to cytokine|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.82|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5103
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HYAL1 Expression in NALM6 Cells: 0.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>