======= HYAL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HYAL3
  * **<color #00a2e8>Official Name</color>**: hyaluronidase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8372|8372]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43820|O43820]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HYAL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HYAL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604038|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro. {ECO:0000250|UniProtKB:Q8VEI3}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco hydro 56|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ovarian follicle atresia|
|positive regulation of acrosomal vesicle exocytosis|
|negative regulation of ovarian follicle development|
|hyaluronoglucuronidase activity|
|regulation of acrosomal vesicle exocytosis|
|negative regulation of female gonad development|
|negative regulation of gonad development|
|regulation of ovarian follicle development|
|penetration of zona pellucida|
|hyalurononglucosaminidase activity|
|cellular response to UV-B|
|positive regulation of acrosome reaction|
|regulation of female gonad development|
|positive regulation of fertilization|
|hyaluronan catabolic process|
|response to UV-B|
|regulation of acrosome reaction|
|acrosomal membrane|
|regulation of gonad development|
|positive regulation of calcium ion-dependent exocytosis|
|sperm midpiece|
|regulation of fertilization|
|hyaluronan metabolic process|
|regulation of calcium ion-dependent exocytosis|
|positive regulation of regulated secretory pathway|
|negative regulation of reproductive process|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|virus receptor activity|
|positive regulation of reproductive process|
|cellular response to UV|
|acrosomal vesicle|
|female gonad development|
|positive regulation of exocytosis|
|development of primary female sexual characteristics|
|viral entry into host cell|
|entry into host cell|
|entry into host|
|female sex differentiation|
|mucopolysaccharide metabolic process|
|cellular response to light stimulus|
|single fertilization|
|response to UV|
|glycosaminoglycan metabolic process|
|interaction with host|
|regulation of reproductive process|
|regulation of regulated secretory pathway|
|aminoglycan metabolic process|
|fertilization|
|cartilage development|
|cellular response to radiation|
|cellular response to interleukin-1|
|carbohydrate derivative catabolic process|
|response to interleukin-1|
|viral life cycle|
|gonad development|
|multi-multicellular organism process|
|development of primary sexual characteristics|
|regulation of exocytosis|
|connective tissue development|
|cellular response to tumor necrosis factor|
|lysosome|
|cytoplasmic vesicle|
|early endosome|
|response to tumor necrosis factor|
|sex differentiation|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|response to virus|
|response to antibiotic|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|positive regulation of secretion by cell|
|reproductive structure development|
|reproductive system development|
|positive regulation of secretion|
|small molecule catabolic process|
|response to radiation|
|carbohydrate metabolic process|
|skeletal system development|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of vesicle-mediated transport|
|developmental process involved in reproduction|
|viral process|
|regulation of secretion by cell|
|regulation of multi-organism process|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|carboxylic acid metabolic process|
|negative regulation of developmental process|
|positive regulation of transport|
|multi-organism reproductive process|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to cytokine|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|reproductive process|
|reproduction|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18339
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HYAL3 Expression in NALM6 Cells: 1.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>