======= IBA57 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IBA57
  * **<color #00a2e8>Official Name</color>**: iron-sulfur cluster assembly factor IBA57
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=200205|200205]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T440|Q5T440]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IBA57&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IBA57|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615316|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene localizes to the mitochondrion and is part of the iron-sulfur cluster assembly pathway. The encoded protein functions late in the biosynthesis of mitochondrial 4Fe-4S proteins. Defects in this gene have been associated with autosomal recessive spastic paraplegia-74 and with multiple mitochondrial dysfunctions syndrome-3. Two transcript variants encoding different isoforms have been found for this gene. The smaller isoform is not likely to be localized to the mitochondrion since it lacks the amino-terminal transit peptide. [provided by RefSeq, Jul 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. {ECO:0000269|PubMed:23462291}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GCV T|
|GCV T C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|iron-sulfur cluster assembly|
|metallo-sulfur cluster assembly|
|heme biosynthetic process|
|porphyrin-containing compound biosynthetic process|
|tetrapyrrole biosynthetic process|
|heme metabolic process|
|porphyrin-containing compound metabolic process|
|pigment biosynthetic process|
|tetrapyrrole metabolic process|
|transferase activity|
|pigment metabolic process|
|cofactor biosynthetic process|
|sulfur compound metabolic process|
|mitochondrial matrix|
|cofactor metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.87|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.7|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.71|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.74|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.76|
|[[:results:exp539|42°C R08 exp539]]|1.77|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.77|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.81|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.83|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.85|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.89|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.94|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.97|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.99|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.07|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.1|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.11|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.11|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.16|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.16|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.22|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.23|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.24|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.25|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.35|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.36|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.41|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.59|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.66|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.91|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|3.2|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|3.29|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|3.35|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.5|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|3.89|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:glrx5|GLRX5]]|0.701|
|[[:human genes:m:mipep|MIPEP]]|0.6|
|[[:human genes:i:isca2|ISCA2]]|0.598|
|[[:human genes:n:nfu1|NFU1]]|0.597|
|[[:human genes:a:acad9|ACAD9]]|0.595|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.583|
|[[:human genes:n:ndufa3|NDUFA3]]|0.579|
|[[:human genes:n:ndufb11|NDUFB11]]|0.578|
|[[:human genes:m:mcat|MCAT]]|0.57|
|[[:human genes:n:ndufb9|NDUFB9]]|0.564|
|[[:human genes:n:nubpl|NUBPL]]|0.555|
|[[:human genes:m:mtg1|MTG1]]|0.551|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.551|
|[[:human genes:m:mto1|MTO1]]|0.548|
|[[:human genes:p:polg|POLG]]|0.542|
|[[:human genes:m:mrpl23|MRPL23]]|0.54|
|[[:human genes:r:rbfa|RBFA]]|0.539|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.539|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.538|
|[[:human genes:m:mrps34|MRPS34]]|0.538|
|[[:human genes:m:mrps5|MRPS5]]|0.535|
|[[:human genes:m:mrpl21|MRPL21]]|0.532|
|[[:human genes:s:slc25a26|SLC25A26]]|0.532|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.515|
|[[:human genes:t:tomm20|TOMM20]]|0.512|
|[[:human genes:f:fars2|FARS2]]|0.511|
|[[:human genes:n:ndufa1|NDUFA1]]|0.51|
|[[:human genes:t:tpk1|TPK1]]|0.505|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.503|
|[[:human genes:g:gfm1|GFM1]]|0.502|
|[[:human genes:c:c12orf65|C12orf65]]|0.502|
|[[:human genes:r:rpusd4|RPUSD4]]|0.502|
|[[:human genes:g:gfm2|GFM2]]|0.5|
|[[:human genes:y:yars2|YARS2]]|0.494|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.493|
|[[:human genes:e:ecsit|ECSIT]]|0.493|
|[[:human genes:p:pet112|PET112]]|0.493|
|[[:human genes:m:mettl1|METTL1]]|0.492|
|[[:human genes:t:tars2|TARS2]]|0.492|
|[[:human genes:n:nars2|NARS2]]|0.488|
|[[:human genes:n:ndufs2|NDUFS2]]|0.488|
|[[:human genes:f:fastkd2|FASTKD2]]|0.487|
|[[:human genes:q:qrsl1|QRSL1]]|0.483|
|[[:human genes:c:c17orf89|C17orf89]]|0.482|
|[[:human genes:n:ndufb6|NDUFB6]]|0.481|
|[[:human genes:s:sco2|SCO2]]|0.481|
|[[:human genes:c:coq7|COQ7]]|0.48|
|[[:human genes:n:ndufa2|NDUFA2]]|0.479|
|[[:human genes:n:ndufb5|NDUFB5]]|0.478|
|[[:human genes:m:mrpl12|MRPL12]]|0.477|
|[[:human genes:g:grsf1|GRSF1]]|0.476|
|[[:human genes:f:foxred1|FOXRED1]]|0.474|
|[[:human genes:m:mrps22|MRPS22]]|0.472|
|[[:human genes:a:abhd11|ABHD11]]|0.472|
|[[:human genes:m:mrps16|MRPS16]]|0.47|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.468|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.465|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.465|
|[[:human genes:c:coq2|COQ2]]|0.464|
|[[:human genes:m:mrpl15|MRPL15]]|0.46|
|[[:human genes:m:mrpl43|MRPL43]]|0.46|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.459|
|[[:human genes:m:mrp63|MRP63]]|0.459|
|[[:human genes:s:sucla2|SUCLA2]]|0.459|
|[[:human genes:i:isca1|ISCA1]]|0.458|
|[[:human genes:m:mrps2|MRPS2]]|0.458|
|[[:human genes:l:lars2|LARS2]]|0.457|
|[[:human genes:c:chchd1|CHCHD1]]|0.456|
|[[:human genes:p:pgm3|PGM3]]|0.455|
|[[:human genes:e:ears2|EARS2]]|0.454|
|[[:human genes:l:lipt2|LIPT2]]|0.454|
|[[:human genes:p:pars2|PARS2]]|0.453|
|[[:human genes:n:ndufa8|NDUFA8]]|0.452|
|[[:human genes:w:wbscr16|WBSCR16]]|0.451|
|[[:human genes:n:nsun4|NSUN4]]|0.45|
|[[:human genes:m:mrps18a|MRPS18A]]|0.45|
|[[:human genes:m:mettl17|METTL17]]|0.447|
|[[:human genes:c:coa3|COA3]]|0.447|
|[[:human genes:m:mrps12|MRPS12]]|0.446|
|[[:human genes:m:mrps21|MRPS21]]|0.444|
|[[:human genes:m:mrps14|MRPS14]]|0.444|
|[[:human genes:c:coq3|COQ3]]|0.443|
|[[:human genes:d:dap3|DAP3]]|0.443|
|[[:human genes:m:mrps25|MRPS25]]|0.437|
|[[:human genes:n:ndufc2|NDUFC2]]|0.437|
|[[:human genes:m:mrps6|MRPS6]]|0.435|
|[[:human genes:p:polg2|POLG2]]|0.435|
|[[:human genes:s:selrc1|SELRC1]]|0.435|
|[[:human genes:s:sfxn4|SFXN4]]|0.434|
|[[:human genes:w:wars2|WARS2]]|0.433|
|[[:human genes:m:mrpl44|MRPL44]]|0.432|
|[[:human genes:v:vars2|VARS2]]|0.431|
|[[:human genes:d:dars2|DARS2]]|0.43|
|[[:human genes:n:ndufa10|NDUFA10]]|0.429|
|[[:human genes:t:tufm|TUFM]]|0.429|
|[[:human genes:n:ndufc1|NDUFC1]]|0.427|
|[[:human genes:d:dnlz|DNLZ]]|0.427|
|[[:human genes:m:mrpl45|MRPL45]]|0.425|
|[[:human genes:m:mtg2|MTG2]]|0.425|
|[[:human genes:s:slc25a19|SLC25A19]]|0.423|
|[[:human genes:p:pmvk|PMVK]]|0.423|
|[[:human genes:b:bcs1l|BCS1L]]|0.423|
|[[:human genes:n:ndufa11|NDUFA11]]|0.422|
|[[:human genes:d:ddx28|DDX28]]|0.422|
|[[:human genes:s:suclg1|SUCLG1]]|0.422|
|[[:human genes:m:mrps27|MRPS27]]|0.422|
|[[:human genes:n:ndufb2|NDUFB2]]|0.421|
|[[:human genes:m:mrpl18|MRPL18]]|0.421|
|[[:human genes:r:rpusd3|RPUSD3]]|0.421|
|[[:human genes:e:eral1|ERAL1]]|0.42|
|[[:human genes:p:pitrm1|PITRM1]]|0.42|
|[[:human genes:n:ndufs7|NDUFS7]]|0.418|
|[[:human genes:p:polrmt|POLRMT]]|0.418|
|[[:human genes:n:ndufb7|NDUFB7]]|0.418|
|[[:human genes:p:ptrhd1|PTRHD1]]|0.418|
|[[:human genes:a:atp5sl|ATP5SL]]|0.417|
|[[:human genes:n:ndufs5|NDUFS5]]|0.417|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.414|
|[[:human genes:m:mrps23|MRPS23]]|0.412|
|[[:human genes:m:mrps11|MRPS11]]|0.412|
|[[:human genes:f:fastkd5|FASTKD5]]|0.412|
|[[:human genes:c:cox11|COX11]]|0.411|
|[[:human genes:r:rars2|RARS2]]|0.411|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.411|
|[[:human genes:n:ndufs8|NDUFS8]]|0.411|
|[[:human genes:t:tmem242|TMEM242]]|0.41|
|[[:human genes:m:mrpl3|MRPL3]]|0.409|
|[[:human genes:a:aars2|AARS2]]|0.409|
|[[:human genes:t:trmt61a|TRMT61A]]|0.408|
|[[:human genes:m:malsu1|MALSU1]]|0.407|
|[[:human genes:h:hars2|HARS2]]|0.405|
|[[:human genes:m:mrpl22|MRPL22]]|0.405|
|[[:human genes:m:mrps26|MRPS26]]|0.405|
|[[:human genes:m:mrps9|MRPS9]]|0.403|
|[[:human genes:f:ftsj2|FTSJ2]]|0.403|
|[[:human genes:p:pet117|PET117]]|0.402|
|[[:human genes:m:mrps33|MRPS33]]|0.401|
|[[:human genes:m:mrpl53|MRPL53]]|0.401|
|[[:human genes:a:adat2|ADAT2]]|0.401|
|[[:human genes:m:mrpl11|MRPL11]]|0.4|
|[[:human genes:m:mterfd1|MTERFD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 724
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IBA57 Expression in NALM6 Cells: 5.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>