======= ICT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL58
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L58
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3396|3396]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14197|Q14197]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ICT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ICT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603000|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. {ECO:0000269|PubMed:20186120}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RF-1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation release factor activity, codon nonspecific|
|aminoacyl-tRNA hydrolase activity|
|mitochondrial large ribosomal subunit|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|protein-containing complex disassembly|
|mitochondrial matrix|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.7|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.81|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.83|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.01|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.05|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2.06|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:ftsj2|FTSJ2]]|0.514|
|[[:human genes:p:pet112|PET112]]|0.504|
|[[:human genes:m:mrps35|MRPS35]]|0.499|
|[[:human genes:m:mtif2|MTIF2]]|0.497|
|[[:human genes:m:mtg1|MTG1]]|0.485|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.474|
|[[:human genes:d:ddx28|DDX28]]|0.47|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.468|
|[[:human genes:m:mrpl1|MRPL1]]|0.467|
|[[:human genes:a:acad9|ACAD9]]|0.462|
|[[:human genes:g:gfm2|GFM2]]|0.462|
|[[:human genes:m:mrps12|MRPS12]]|0.461|
|[[:human genes:m:mrpl21|MRPL21]]|0.461|
|[[:human genes:n:nars2|NARS2]]|0.461|
|[[:human genes:n:ndufb7|NDUFB7]]|0.456|
|[[:human genes:n:ndufs2|NDUFS2]]|0.451|
|[[:human genes:f:fastkd2|FASTKD2]]|0.449|
|[[:human genes:n:ndufa11|NDUFA11]]|0.448|
|[[:human genes:m:mettl17|METTL17]]|0.442|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.442|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.441|
|[[:human genes:m:malsu1|MALSU1]]|0.437|
|[[:human genes:g:grsf1|GRSF1]]|0.436|
|[[:human genes:c:coq7|COQ7]]|0.435|
|[[:human genes:m:mrps21|MRPS21]]|0.434|
|[[:human genes:m:mipep|MIPEP]]|0.43|
|[[:human genes:m:mto1|MTO1]]|0.429|
|[[:human genes:m:mcat|MCAT]]|0.429|
|[[:human genes:s:sfxn4|SFXN4]]|0.428|
|[[:human genes:n:ndufb11|NDUFB11]]|0.428|
|[[:human genes:n:nsun4|NSUN4]]|0.428|
|[[:human genes:c:coq2|COQ2]]|0.428|
|[[:human genes:m:mrpl18|MRPL18]]|0.427|
|[[:human genes:n:nubpl|NUBPL]]|0.426|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.426|
|[[:human genes:m:mrps5|MRPS5]]|0.426|
|[[:human genes:e:ecsit|ECSIT]]|0.426|
|[[:human genes:m:mrpl23|MRPL23]]|0.426|
|[[:human genes:p:prepl|PREPL]]|0.425|
|[[:human genes:n:ndufb10|NDUFB10]]|0.425|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.424|
|[[:human genes:c:clpp|CLPP]]|0.424|
|[[:human genes:p:ptcd1|PTCD1]]|0.422|
|[[:human genes:e:ears2|EARS2]]|0.421|
|[[:human genes:l:lars2|LARS2]]|0.421|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.421|
|[[:human genes:n:ndufs1|NDUFS1]]|0.42|
|[[:human genes:m:mrpl2|MRPL2]]|0.416|
|[[:human genes:n:ndufc2|NDUFC2]]|0.414|
|[[:human genes:n:ndufa1|NDUFA1]]|0.414|
|[[:human genes:n:ndufb4|NDUFB4]]|0.413|
|[[:human genes:g:glrx5|GLRX5]]|0.412|
|[[:human genes:m:mrpl45|MRPL45]]|0.411|
|[[:human genes:m:mrpl47|MRPL47]]|0.411|
|[[:human genes:n:ndufa8|NDUFA8]]|0.405|
|[[:human genes:n:ndufb6|NDUFB6]]|0.405|
|[[:human genes:q:qrsl1|QRSL1]]|0.404|
|[[:human genes:a:aars2|AARS2]]|0.401|
|[[:human genes:e:eral1|ERAL1]]|0.401|
|[[:human genes:n:ndufa3|NDUFA3]]|0.4|
|[[:human genes:r:rpusd3|RPUSD3]]|0.4|
|[[:human genes:n:ndufb9|NDUFB9]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1146
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ICT1 Expression in NALM6 Cells: 4.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>