======= IFNG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFNG
  * **<color #00a2e8>Official Name</color>**: interferon gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3458|3458]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01579|P01579]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFNG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFNG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147570|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IFN-gamma|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interferon-gamma receptor binding|
|positive regulation of fructose 1,6-bisphosphate metabolic process|
|regulation of carbohydrate phosphatase activity|
|regulation of fructose 1,6-bisphosphate 1-phosphatase activity|
|regulation of fructose 1,6-bisphosphate metabolic process|
|positive regulation of iron ion transmembrane transport|
|positive regulation of iron ion transport|
|positive regulation of iron ion import across plasma membrane|
|positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity|
|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response|
|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|
|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response|
|regulation of iron ion import across plasma membrane|
|positive regulation of calcidiol 1-monooxygenase activity|
|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|
|negative regulation of tau-protein kinase activity|
|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|
|positive regulation of vitamin D biosynthetic process|
|regulation of tumor necrosis factor (ligand) superfamily member 11 production|
|regulation of iron ion transmembrane transport|
|positive regulation of vitamin metabolic process|
|positive regulation of interleukin-23 production|
|positive regulation of NMDA glutamate receptor activity|
|positive regulation of core promoter binding|
|positive regulation of interleukin-1 biosynthetic process|
|regulation of interleukin-1 biosynthetic process|
|regulation of iron ion transport|
|regulation of calcidiol 1-monooxygenase activity|
|positive regulation of interleukin-1 beta biosynthetic process|
|regulation of interleukin-1 beta biosynthetic process|
|regulation of core promoter binding|
|regulation of interleukin-23 production|
|negative regulation of amyloid-beta clearance|
|regulation of vitamin D biosynthetic process|
|positive regulation of cellular respiration|
|positive regulation of MHC class II biosynthetic process|
|regulation of protein ADP-ribosylation|
|regulation of tau-protein kinase activity|
|positive regulation of hormone biosynthetic process|
|positive regulation of chemokine biosynthetic process|
|positive regulation of receptor biosynthetic process|
|regulation of vitamin metabolic process|
|regulation of MHC class II biosynthetic process|
|positive regulation of killing of cells of other organism|
|positive regulation of regulatory T cell differentiation|
|negative regulation of interleukin-17 production|
|positive regulation of smooth muscle cell apoptotic process|
|positive regulation of amyloid-beta formation|
|positive regulation of exosomal secretion|
|regulation of chemokine biosynthetic process|
|positive regulation of nitric-oxide synthase biosynthetic process|
|positive regulation of membrane protein ectodomain proteolysis|
|positive regulation of hormone metabolic process|
|regulation of amyloid-beta clearance|
|positive regulation of glutamate receptor signaling pathway|
|regulation of killing of cells of other organism|
|positive regulation of steroid biosynthetic process|
|regulation of exosomal secretion|
|regulation of nitric-oxide synthase biosynthetic process|
|positive regulation of amyloid precursor protein catabolic process|
|astrocyte activation|
|positive regulation of peptidyl-serine phosphorylation of STAT protein|
|positive regulation of tumor necrosis factor secretion|
|positive regulation of tumor necrosis factor biosynthetic process|
|regulation of peptidyl-serine phosphorylation of STAT protein|
|positive regulation of protein deacetylation|
|regulation of membrane protein ectodomain proteolysis|
|positive regulation of glycolytic process|
|regulation of receptor biosynthetic process|
|regulation of smooth muscle cell apoptotic process|
|regulation of response to interferon-gamma|
|regulation of interferon-gamma-mediated signaling pathway|
|positive regulation of alcohol biosynthetic process|
|positive regulation of transcription regulatory region DNA binding|
|positive regulation of osteoclast differentiation|
|positive regulation of monooxygenase activity|
|positive regulation of steroid metabolic process|
|regulation of amyloid-beta formation|
|regulation of hormone biosynthetic process|
|positive regulation of muscle cell apoptotic process|
|regulation of tumor necrosis factor secretion|
|regulation of interleukin-17 production|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of regulatory T cell differentiation|
|microglial cell activation|
|regulation of tumor necrosis factor biosynthetic process|
|regulation of cellular respiration|
|leukocyte activation involved in inflammatory response|
|regulation of amyloid precursor protein catabolic process|
|positive regulation of phosphatase activity|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of signaling receptor activity|
|positive regulation of interleukin-12 production|
|astrocyte development|
|regulation of NMDA receptor activity|
|positive regulation of protein import into nucleus|
|glial cell activation|
|regulation of hormone metabolic process|
|receptor signaling pathway via JAK-STAT|
|positive regulation of protein import|
|receptor signaling pathway via STAT|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|neuroinflammatory response|
|negative regulation of epithelial cell differentiation|
|regulation of protein deacetylation|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of nucleotide metabolic process|
|positive regulation of ATP metabolic process|
|negative regulation of smooth muscle cell proliferation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of alpha-beta T cell differentiation|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|response to interleukin-12|
|positive regulation of reactive oxygen species biosynthetic process|
|macrophage activation|
|positive regulation of interleukin-1 beta production|
|regulation of transcription regulatory region DNA binding|
|positive regulation of oxidoreductase activity|
|astrocyte differentiation|
|regulation of interleukin-12 production|
|regulation of monooxygenase activity|
|regulation of protein import into nucleus|
|positive regulation of protein localization to plasma membrane|
|positive regulation of myeloid leukocyte differentiation|
|positive regulation of DNA binding|
|regulation of nitric oxide biosynthetic process|
|positive regulation of chemokine production|
|regulation of protein import|
|positive regulation of interleukin-1 production|
|positive regulation of dephosphorylation|
|regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|positive regulation of protein localization to cell periphery|
|positive regulation of nucleocytoplasmic transport|
|regulation of glutamate receptor signaling pathway|
|regulation of osteoclast differentiation|
|positive regulation of cell killing|
|positive regulation of cytokine biosynthetic process|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of muscle cell apoptotic process|
|positive regulation of phagocytosis|
|positive regulation of cation channel activity|
|interferon-gamma-mediated signaling pathway|
|regulation of neurotransmitter receptor activity|
|regulation of alcohol biosynthetic process|
|positive regulation of protein localization to nucleus|
|regulation of chemokine production|
|regulation of glycolytic process|
|positive regulation of carbohydrate metabolic process|
|regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of lipid biosynthetic process|
|regulation of interleukin-1 beta production|
|positive regulation of T cell differentiation|
|positive regulation of receptor signaling pathway via JAK-STAT|
|regulation of reactive oxygen species biosynthetic process|
|positive regulation of tumor necrosis factor production|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|regulation of steroid biosynthetic process|
|regulation of carbohydrate catabolic process|
|positive regulation of exocytosis|
|positive regulation of myeloid cell differentiation|
|positive regulation of neuron death|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|regulation of interleukin-1 production|
|regulation of protein localization to plasma membrane|
|regulation of oxidoreductase activity|
|positive regulation of reactive oxygen species metabolic process|
|regulation of phagocytosis|
|extrinsic apoptotic signaling pathway|
|regulation of cell killing|
|positive regulation of ion transmembrane transporter activity|
|regulation of cytokine biosynthetic process|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of nucleocytoplasmic transport|
|glial cell development|
|positive regulation of transporter activity|
|regulation of steroid metabolic process|
|regulation of protein localization to cell periphery|
|regulation of myeloid leukocyte differentiation|
|regulation of purine nucleotide metabolic process|
|regulation of protein localization to nucleus|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|positive regulation of autophagy|
|positive regulation of protein localization to membrane|
|regulation of DNA binding|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of smooth muscle cell proliferation|
|regulation of receptor signaling pathway via STAT|
|regulation of peptidyl-serine phosphorylation|
|regulation of T cell differentiation|
|positive regulation of small molecule metabolic process|
|positive regulation of cytokine secretion|
|positive regulation of epithelial cell migration|
|positive regulation of cation transmembrane transport|
|regulation of epithelial cell differentiation|
|positive regulation of lipid metabolic process|
|cell cycle arrest|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|positive regulation of cellular amide metabolic process|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of intracellular protein transport|
|positive regulation of ion transmembrane transport|
|regulation of generation of precursor metabolites and energy|
|cellular response to interferon-gamma|
|regulation of cytokine-mediated signaling pathway|
|regulation of lymphocyte differentiation|
|glial cell differentiation|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|cytokine activity|
|regulation of response to cytokine stimulus|
|regulation of phosphatase activity|
|regulation of insulin secretion|
|positive regulation of binding|
|regulation of reactive oxygen species metabolic process|
|response to interferon-gamma|
|regulation of lipid biosynthetic process|
|positive regulation of hemopoiesis|
|regulation of protein localization to membrane|
|positive regulation of peptidyl-tyrosine phosphorylation|
|defense response to virus|
|positive regulation of transmembrane transport|
|positive regulation of T cell activation|
|regulation of carbohydrate metabolic process|
|regulation of cytokine secretion|
|positive regulation of intracellular transport|
|regulation of peptide hormone secretion|
|regulation of dephosphorylation|
|gliogenesis|
|positive regulation of protein catabolic process|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of epithelial cell migration|
|regulation of exocytosis|
|negative regulation of protein kinase activity|
|regulation of myeloid cell differentiation|
|regulation of intracellular protein transport|
|negative regulation of kinase activity|
|positive regulation of protein complex assembly|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|positive regulation of ion transport|
|negative regulation of transferase activity|
|regulation of transporter activity|
|response to virus|
|apoptotic signaling pathway|
|positive regulation of peptide secretion|
|regulation of leukocyte cell-cell adhesion|
|regulation of neuron death|
|regulation of T cell activation|
|positive regulation of cellular protein localization|
|regulation of autophagy|
|regulation of cation transmembrane transport|
|positive regulation of protein serine/threonine kinase activity|
|humoral immune response|
|regulation of intracellular transport|
|regulation of neurotransmitter levels|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|positive regulation of cellular catabolic process|
|regulation of binding|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|regulation of cellular amide metabolic process|
|negative regulation of protein phosphorylation|
|positive regulation of cell activation|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|positive regulation of secretion|
|negative regulation of phosphorylation|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of protein complex assembly|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|regulation of response to biotic stimulus|
|positive regulation of cell motility|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|negative regulation of protein modification process|
|regulation of leukocyte activation|
|adaptive immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|regulation of growth|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of ion transport|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|regulation of kinase activity|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|apoptotic process|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|defense response to other organism|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of catabolic process|
|cell cycle process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|cell activation|
|cell death|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|cell cycle|
|defense response|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.73|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14978
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFNG Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>