======= IFNGR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFNGR1
  * **<color #00a2e8>Official Name</color>**: interferon gamma receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3459|3459]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15260|P15260]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFNGR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFNGR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107470|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents (PubMed:20015550). {ECO:0000269|PubMed:10986460, ECO:0000269|PubMed:20015550, ECO:0000269|PubMed:2971451, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7617032, ECO:0000269|PubMed:7673114}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tissue fac|
|IFNGR1|
|Interfer-bind|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interferon-gamma receptor activity|
|negative regulation of amyloid-beta clearance|
|positive regulation of amyloid-beta formation|
|regulation of amyloid-beta clearance|
|positive regulation of amyloid precursor protein catabolic process|
|astrocyte activation|
|positive regulation of tumor necrosis factor secretion|
|regulation of interferon-gamma-mediated signaling pathway|
|regulation of response to interferon-gamma|
|regulation of amyloid-beta formation|
|regulation of tumor necrosis factor secretion|
|microglial cell activation|
|leukocyte activation involved in inflammatory response|
|regulation of amyloid precursor protein catabolic process|
|astrocyte development|
|glial cell activation|
|cytokine binding|
|neuroinflammatory response|
|cytokine receptor activity|
|macrophage activation|
|astrocyte differentiation|
|interferon-gamma-mediated signaling pathway|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|glial cell development|
|positive regulation of cytokine secretion|
|regulation of tumor necrosis factor production|
|positive regulation of cellular amide metabolic process|
|regulation of tumor necrosis factor superfamily cytokine production|
|cellular response to interferon-gamma|
|regulation of cytokine-mediated signaling pathway|
|glial cell differentiation|
|regulation of response to cytokine stimulus|
|response to interferon-gamma|
|regulation of cytokine secretion|
|gliogenesis|
|positive regulation of protein secretion|
|response to virus|
|positive regulation of peptide secretion|
|regulation of cellular amide metabolic process|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|inflammatory response|
|regulation of response to biotic stimulus|
|myeloid leukocyte activation|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of secretion|
|leukocyte activation|
|defense response to other organism|
|central nervous system development|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|cell activation|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|regulation of response to stress|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.79|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8364
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFNGR1 Expression in NALM6 Cells: 5.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>