======= IFT122 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFT122
  * **<color #00a2e8>Official Name</color>**: intraflagellar transport 122
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55764|55764]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HBG6|Q9HBG6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFT122&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFT122|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606045|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ciliary receptor clustering involved in smoothened signaling pathway|
|negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning|
|embryonic heart tube left/right pattern formation|
|intraciliary anterograde transport|
|signal transduction downstream of smoothened|
|embryonic body morphogenesis|
|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|
|intraciliary transport particle A|
|intraciliary retrograde transport|
|dorsal/ventral neural tube patterning|
|left/right pattern formation|
|spinal cord dorsal/ventral patterning|
|spinal cord patterning|
|negative regulation of smoothened signaling pathway|
|non-motile cilium|
|embryonic forelimb morphogenesis|
|neural tube patterning|
|ciliary base|
|photoreceptor connecting cilium|
|intraciliary transport involved in cilium assembly|
|forelimb morphogenesis|
|non-motile cilium assembly|
|body morphogenesis|
|ciliary tip|
|receptor clustering|
|protein localization to cilium|
|intraciliary transport|
|embryonic digit morphogenesis|
|protein transport along microtubule|
|microtubule-based protein transport|
|smoothened signaling pathway|
|embryonic heart tube development|
|regulation of smoothened signaling pathway|
|dorsal/ventral pattern formation|
|localization within membrane|
|neural tube closure|
|tube closure|
|primary neural tube formation|
|neural tube formation|
|spinal cord development|
|camera-type eye morphogenesis|
|embryonic epithelial tube formation|
|negative regulation of epithelial cell proliferation|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|epithelial tube formation|
|ciliary basal body|
|morphogenesis of embryonic epithelium|
|tube formation|
|eye morphogenesis|
|limb morphogenesis|
|appendage morphogenesis|
|transport along microtubule|
|neural tube development|
|cytoskeleton-dependent intracellular transport|
|appendage development|
|limb development|
|microtubule-based transport|
|cilium|
|sensory organ morphogenesis|
|protein-containing complex localization|
|microtubule-based movement|
|epithelial tube morphogenesis|
|negative regulation of nervous system development|
|camera-type eye development|
|regionalization|
|regulation of epithelial cell proliferation|
|cilium assembly|
|eye development|
|visual system development|
|sensory system development|
|cilium organization|
|establishment of protein localization to organelle|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein localization to membrane|
|heart development|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|microtubule-based process|
|negative regulation of cell population proliferation|
|protein localization to organelle|
|organelle assembly|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|intracellular protein transport|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12228
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFT122 Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>