======= IGFBP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IGFBP2
  * **<color #00a2e8>Official Name</color>**: insulin like growth factor binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3485|3485]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18065|P18065]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IGFBP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IGFBP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/146731|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. {ECO:0000269|PubMed:19081843}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IGFBP|
|Thyroglobulin 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|insulin-like growth factor II binding|
|insulin-like growth factor I binding|
|positive regulation of activated T cell proliferation|
|response to lithium ion|
|regulation of insulin-like growth factor receptor signaling pathway|
|regulation of activated T cell proliferation|
|response to estrogen|
|positive regulation of T cell proliferation|
|response to retinoic acid|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|response to estradiol|
|positive regulation of leukocyte proliferation|
|response to glucocorticoid|
|regulation of T cell proliferation|
|response to corticosteroid|
|negative regulation of canonical Wnt signaling pathway|
|female pregnancy|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|negative regulation of Wnt signaling pathway|
|regulation of mononuclear cell proliferation|
|multi-multicellular organism process|
|response to mechanical stimulus|
|response to nutrient|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|cytoplasmic vesicle|
|positive regulation of cell-cell adhesion|
|aging|
|regulation of canonical Wnt signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|apical plasma membrane|
|response to steroid hormone|
|signaling receptor binding|
|response to acid chemical|
|positive regulation of lymphocyte activation|
|regulation of Wnt signaling pathway|
|response to metal ion|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|response to nutrient levels|
|regulation of lymphocyte activation|
|response to extracellular stimulus|
|response to inorganic substance|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|regulation of cell activation|
|regulation of growth|
|regulation of cell adhesion|
|response to lipid|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|multi-organism reproductive process|
|response to drug|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.74|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.477|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10788
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IGFBP2 Expression in NALM6 Cells: 2.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>