======= IKBKB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IKBKB
  * **<color #00a2e8>Official Name</color>**: inhibitor of nuclear factor kappa B kinase subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3551|3551]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14920|O14920]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IKBKB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IKBKB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603258|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF- dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation. {ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IKKbetaNEMObind|
|Kdo|
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|IkappaB kinase activity|
|negative regulation of bicellular tight junction assembly|
|negative regulation of myosin-light-chain-phosphatase activity|
|regulation of myosin-light-chain-phosphatase activity|
|IkappaB kinase complex|
|CD40 receptor complex|
|I-kappaB phosphorylation|
|regulation of establishment of endothelial barrier|
|regulation of endothelial cell development|
|regulation of bicellular tight junction assembly|
|negative regulation of cell junction assembly|
|TRIF-dependent toll-like receptor signaling pathway|
|MyD88-independent toll-like receptor signaling pathway|
|regulation of endothelial cell differentiation|
|cortical actin cytoskeleton organization|
|cortical cytoskeleton organization|
|cytoplasmic side of plasma membrane|
|regulation of tumor necrosis factor-mediated signaling pathway|
|scaffold protein binding|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|I-kappaB kinase/NF-kappaB signaling|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|regulation of cell junction assembly|
|interleukin-1-mediated signaling pathway|
|antigen processing and presentation of peptide antigen via MHC class I|
|toll-like receptor signaling pathway|
|stress-activated MAPK cascade|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|regulation of phosphoprotein phosphatase activity|
|tumor necrosis factor-mediated signaling pathway|
|pattern recognition receptor signaling pathway|
|regulation of protein dephosphorylation|
|regulation of epithelial cell differentiation|
|stress-activated protein kinase signaling cascade|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of cytokine-mediated signaling pathway|
|Fc-epsilon receptor signaling pathway|
|peptidyl-serine phosphorylation|
|cellular response to interleukin-1|
|T cell receptor signaling pathway|
|regulation of response to cytokine stimulus|
|regulation of phosphatase activity|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|protein localization to plasma membrane|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|antigen processing and presentation of peptide antigen|
|response to interleukin-1|
|peptidyl-serine modification|
|regulation of dephosphorylation|
|antigen processing and presentation|
|membrane raft|
|protein localization to cell periphery|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|protein kinase activity|
|cellular response to tumor necrosis factor|
|Fc receptor signaling pathway|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|response to virus|
|antigen receptor-mediated signaling pathway|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|protein serine/threonine kinase activity|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of DNA-binding transcription factor activity|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|protein kinase binding|
|positive regulation of defense response|
|protein localization to membrane|
|immune response-regulating cell surface receptor signaling pathway|
|protein heterodimerization activity|
|actin cytoskeleton organization|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|actin filament-based process|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|cytokine-mediated signaling pathway|
|viral process|
|negative regulation of cellular component organization|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|symbiotic process|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|positive regulation of immune response|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell development|
|defense response to other organism|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|identical protein binding|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of transcription by RNA polymerase II|
|regulation of hydrolase activity|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|ATP binding|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.73|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.73|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7470
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IKBKB Expression in NALM6 Cells: 6.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>