======= IL10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL10
  * **<color #00a2e8>Official Name</color>**: interleukin 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3586|3586]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22301|P22301]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/124092|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-10 receptor binding|
|negative regulation of chronic inflammatory response to antigenic stimulus|
|negative regulation of cytokine activity|
|negative regulation of interferon-alpha biosynthetic process|
|negative regulation of interleukin-18 production|
|negative regulation of sensory perception of pain|
|positive regulation of B cell apoptotic process|
|regulation of chronic inflammatory response to antigenic stimulus|
|negative regulation of myeloid dendritic cell activation|
|response to carbon monoxide|
|negative regulation of chemokine (C-C motif) ligand 5 production|
|negative regulation of chronic inflammatory response|
|regulation of cytokine activity|
|regulation of hydrogen peroxide-induced neuron death|
|negative regulation of hydrogen peroxide-induced neuron death|
|negative regulation of MHC class II biosynthetic process|
|receptor biosynthetic process|
|negative regulation of cytokine secretion involved in immune response|
|regulation of myeloid dendritic cell activation|
|regulation of interferon-alpha biosynthetic process|
|negative regulation of interferon-alpha production|
|negative regulation of tumor necrosis factor biosynthetic process|
|cytoplasmic sequestering of NF-kappaB|
|regulation of interleukin-18 production|
|endothelial cell apoptotic process|
|type 2 immune response|
|negative regulation of membrane protein ectodomain proteolysis|
|regulation of chronic inflammatory response|
|regulation of chemokine (C-C motif) ligand 5 production|
|positive regulation of MHC class II biosynthetic process|
|regulation of cell-cell adhesion involved in gastrulation|
|negative regulation of heterotypic cell-cell adhesion|
|regulation of complement-dependent cytotoxicity|
|negative regulation of inflammatory response to antigenic stimulus|
|negative regulation of receptor binding|
|branching involved in labyrinthine layer morphogenesis|
|regulation of MHC class II biosynthetic process|
|response to inactivity|
|negative regulation of nitric oxide biosynthetic process|
|negative regulation of nitric oxide metabolic process|
|negative regulation of hydrogen peroxide-induced cell death|
|negative regulation of interleukin-12 production|
|regulation of cytokine secretion involved in immune response|
|negative regulation of response to reactive oxygen species|
|cellular response to hepatocyte growth factor stimulus|
|positive regulation of heterotypic cell-cell adhesion|
|negative regulation of B cell proliferation|
|regulation of B cell apoptotic process|
|cytoplasmic sequestering of transcription factor|
|positive regulation of lymphocyte apoptotic process|
|negative regulation of vascular smooth muscle cell proliferation|
|negative regulation of interleukin-8 production|
|response to hepatocyte growth factor|
|negative regulation of chemokine production|
|negative regulation of cellular response to drug|
|negative regulation of oxidative stress-induced neuron death|
|labyrinthine layer morphogenesis|
|regulation of hydrogen peroxide-induced cell death|
|defense response to protozoan|
|regulation of membrane protein ectodomain proteolysis|
|positive regulation of macrophage activation|
|response to protozoan|
|regulation of receptor binding|
|cytoplasmic sequestering of protein|
|regulation of inflammatory response to antigenic stimulus|
|negative regulation of nervous system process|
|negative regulation of cytokine production involved in immune response|
|regulation of heterotypic cell-cell adhesion|
|regulation of oxidative stress-induced neuron death|
|embryonic placenta morphogenesis|
|negative regulation of reactive oxygen species biosynthetic process|
|epithelial cell apoptotic process|
|positive regulation of leukocyte apoptotic process|
|negative regulation of response to drug|
|regulation of interferon-alpha production|
|regulation of tumor necrosis factor biosynthetic process|
|negative regulation of endothelial cell apoptotic process|
|negative regulation of B cell activation|
|liver regeneration|
|negative regulation of cytokine biosynthetic process|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|positive regulation of vascular smooth muscle cell proliferation|
|regulation of isotype switching|
|negative regulation of interferon-gamma production|
|negative regulation of interleukin-1 production|
|regulation of response to reactive oxygen species|
|regulation of cellular response to drug|
|negative regulation of production of molecular mediator of immune response|
|cellular response to estradiol stimulus|
|regulation of gastrulation|
|positive regulation of sprouting angiogenesis|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|B cell proliferation|
|regulation of pri-miRNA transcription by RNA polymerase II|
|negative regulation of epithelial cell apoptotic process|
|negative regulation of interleukin-6 production|
|negative regulation of type I interferon production|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of cellular response to oxidative stress|
|negative regulation of smooth muscle cell proliferation|
|labyrinthine layer development|
|interleukin-12-mediated signaling pathway|
|negative regulation of response to oxidative stress|
|cellular response to interleukin-12|
|response to interleukin-12|
|regulation of vascular smooth muscle cell proliferation|
|regulation of endothelial cell apoptotic process|
|regulation of B cell mediated immunity|
|regulation of immunoglobulin mediated immune response|
|regulation of macrophage activation|
|regulation of lymphocyte apoptotic process|
|negative regulation of reactive oxygen species metabolic process|
|regulation of interleukin-12 production|
|regulation of nitric oxide biosynthetic process|
|negative regulation of tumor necrosis factor production|
|negative regulation of T cell proliferation|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|regulation of B cell proliferation|
|regulation of oxidative stress-induced cell death|
|regulation of immunoglobulin production|
|response to activity|
|negative regulation of cytokine secretion|
|regulation of sprouting angiogenesis|
|regulation of interleukin-8 production|
|animal organ regeneration|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|regulation of cellular response to oxidative stress|
|regulation of chemokine production|
|negative regulation of leukocyte proliferation|
|regulation of epithelial cell apoptotic process|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of leukocyte apoptotic process|
|negative regulation of autophagy|
|lymphocyte proliferation|
|positive regulation of receptor signaling pathway via JAK-STAT|
|regulation of response to oxidative stress|
|regulation of cytokine production involved in immune response|
|positive regulation of smooth muscle cell proliferation|
|regulation of reactive oxygen species biosynthetic process|
|mononuclear cell proliferation|
|embryonic placenta development|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of endothelial cell proliferation|
|regulation of interleukin-1 production|
|leukocyte proliferation|
|regulation of response to drug|
|regulation of interferon-gamma production|
|regulation of cell killing|
|negative regulation of protein binding|
|regulation of DNA recombination|
|regulation of cytokine biosynthetic process|
|receptor metabolic process|
|maintenance of protein location|
|B cell differentiation|
|negative regulation of T cell activation|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|liver development|
|regulation of type I interferon production|
|regulation of embryonic development|
|hepaticobiliary system development|
|regulation of endothelial cell proliferation|
|regulation of receptor signaling pathway via JAK-STAT|
|negative regulation of protein secretion|
|regulation of smooth muscle cell proliferation|
|negative regulation of protein catabolic process|
|regulation of receptor signaling pathway via STAT|
|response to estradiol|
|regulation of nervous system process|
|negative regulation of inflammatory response|
|positive regulation of cytokine secretion|
|negative regulation of peptide secretion|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|negative regulation of lymphocyte activation|
|leukocyte chemotaxis|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to glucocorticoid|
|regulation of tumor necrosis factor production|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|regulation of tumor necrosis factor superfamily cytokine production|
|placenta development|
|B cell activation|
|regeneration|
|regulation of T cell proliferation|
|protein dimerization activity|
|morphogenesis of a branching epithelium|
|regulation of adaptive immune response|
|negative regulation of DNA-binding transcription factor activity|
|response to corticosteroid|
|growth factor activity|
|positive regulation of angiogenesis|
|maintenance of location|
|regulation of response to wounding|
|morphogenesis of a branching structure|
|negative regulation of binding|
|regulation of signaling receptor activity|
|cytokine activity|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|regulation of reactive oxygen species metabolic process|
|negative regulation of protein transport|
|positive regulation of vasculature development|
|cellular response to lipopolysaccharide|
|negative regulation of establishment of protein localization|
|positive regulation of epithelial cell proliferation|
|cellular response to molecule of bacterial origin|
|negative regulation of cell activation|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|negative regulation of neuron death|
|negative regulation of defense response|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|cell chemotaxis|
|regulation of mononuclear cell proliferation|
|cellular response to biotic stimulus|
|regulation of synapse organization|
|regulation of protein binding|
|regulation of leukocyte proliferation|
|response to insulin|
|regulation of synapse structure or activity|
|negative regulation of secretion|
|lymphocyte differentiation|
|negative regulation of cellular catabolic process|
|positive regulation of cell-cell adhesion|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|aging|
|regulation of angiogenesis|
|positive regulation of peptide secretion|
|regulation of leukocyte cell-cell adhesion|
|negative regulation of mitotic cell cycle|
|negative regulation of catabolic process|
|regulation of neuron death|
|response to lipopolysaccharide|
|regulation of T cell activation|
|regulation of vasculature development|
|response to molecule of bacterial origin|
|response to steroid hormone|
|defense response to bacterium|
|leukocyte differentiation|
|regulation of autophagy|
|regulation of epithelial cell proliferation|
|regulation of inflammatory response|
|negative regulation of proteolysis|
|regulation of neurotransmitter levels|
|regulation of DNA metabolic process|
|negative regulation of response to external stimulus|
|regulation of binding|
|in utero embryonic development|
|positive regulation of cell cycle|
|leukocyte migration|
|lymphocyte activation|
|regulation of protein catabolic process|
|response to peptide hormone|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of secretion by cell|
|gland development|
|positive regulation of cell activation|
|reproductive structure development|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|response to peptide|
|negative regulation of transport|
|regulation of peptide secretion|
|inflammatory response|
|cellular response to growth factor stimulus|
|response to toxic substance|
|regulation of lymphocyte activation|
|cellular response to lipid|
|response to growth factor|
|cellular response to organic cyclic compound|
|chemotaxis|
|taxis|
|cell population proliferation|
|hemopoiesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of cell cycle|
|regulation of system process|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|regulation of cell activation|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|regulation of cellular catabolic process|
|response to lipid|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|leukocyte activation|
|defense response to other organism|
|cell migration|
|embryo development|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell activation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|epithelium development|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.544|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18018
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL10 Expression in NALM6 Cells: 1.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>