======= IL12A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL12A
  * **<color #00a2e8>Official Name</color>**: interleukin 12A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3592|3592]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29459|P29459]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL12A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL12A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/161560|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-27 binding|
|interleukin-12 beta subunit binding|
|late endosome lumen|
|interleukin-12 complex|
|T-helper 1 cell activation|
|T-helper 1 cell cytokine production|
|interleukin-12 receptor binding|
|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|
|CD4-positive, alpha-beta T cell cytokine production|
|positive regulation of natural killer cell mediated immune response to tumor cell|
|positive regulation of NK T cell activation|
|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|
|positive regulation of dendritic cell chemotaxis|
|regulation of natural killer cell mediated immune response to tumor cell|
|regulation of dendritic cell chemotaxis|
|regulation of NK T cell activation|
|T cell cytokine production|
|positive regulation of response to tumor cell|
|interleukin-35-mediated signaling pathway|
|positive regulation of immune response to tumor cell|
|negative regulation of interleukin-17 production|
|regulation of response to tumor cell|
|regulation of immune response to tumor cell|
|positive regulation of smooth muscle cell apoptotic process|
|response to UV-B|
|T-helper 1 type immune response|
|positive regulation of natural killer cell activation|
|cytokine production involved in immune response|
|defense response to protozoan|
|response to protozoan|
|regulation of smooth muscle cell apoptotic process|
|positive regulation of T cell mediated cytotoxicity|
|positive regulation of muscle cell apoptotic process|
|regulation of interleukin-17 production|
|positive regulation of natural killer cell mediated cytotoxicity|
|cellular response to virus|
|regulation of natural killer cell activation|
|positive regulation of natural killer cell mediated immunity|
|regulation of T cell mediated cytotoxicity|
|CD4-positive, alpha-beta T cell activation|
|T cell mediated immunity|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|negative regulation of smooth muscle cell proliferation|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|positive regulation of T cell mediated immunity|
|response to interleukin-12|
|positive regulation of leukocyte mediated cytotoxicity|
|positive regulation of alpha-beta T cell activation|
|alpha-beta T cell activation|
|positive regulation of interferon-gamma production|
|positive regulation of cell killing|
|regulation of muscle cell apoptotic process|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of T cell mediated immunity|
|regulation of leukocyte mediated cytotoxicity|
|regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of T cell differentiation|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of leukocyte chemotaxis|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|defense response to Gram-positive bacterium|
|positive regulation of T cell proliferation|
|extrinsic apoptotic signaling pathway|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|regulation of leukocyte chemotaxis|
|positive regulation of leukocyte migration|
|positive regulation of lymphocyte proliferation|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of mononuclear cell proliferation|
|regulation of smooth muscle cell proliferation|
|positive regulation of leukocyte mediated immunity|
|regulation of receptor signaling pathway via STAT|
|positive regulation of chemotaxis|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|response to UV|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|cell cycle arrest|
|positive regulation of leukocyte differentiation|
|cytokine production|
|regulation of lymphocyte mediated immunity|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|growth factor activity|
|regulation of lymphocyte differentiation|
|cytokine activity|
|production of molecular mediator of immune response|
|cellular response to lipopolysaccharide|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular response to molecule of bacterial origin|
|regulation of leukocyte migration|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of chemotaxis|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|T cell activation|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|lymphocyte mediated immunity|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to virus|
|apoptotic signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|endoplasmic reticulum lumen|
|response to light stimulus|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|defense response to bacterium|
|positive regulation of innate immune response|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|response to radiation|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|protein heterodimerization activity|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|cellular response to lipid|
|positive regulation of cell motility|
|regulation of response to biotic stimulus|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cell population proliferation|
|negative regulation of cell cycle|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|adaptive immune response|
|cell surface|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|apoptotic process|
|leukocyte activation|
|defense response to other organism|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|cell cycle process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|localization of cell|
|cell motility|
|cell death|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|cell cycle|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.06|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.75|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6413
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL12A Expression in NALM6 Cells: -3.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>