======= IL13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL13
  * **<color #00a2e8>Official Name</color>**: interleukin 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3596|3596]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35225|P35225]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147683|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity). {ECO:0000250|UniProtKB:P20109, ECO:0000269|PubMed:8096327, ECO:0000269|PubMed:8097324}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL13|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of pancreatic stellate cell proliferation|
|positive regulation of lung goblet cell differentiation|
|regulation of lung goblet cell differentiation|
|interleukin-13 receptor binding|
|negative regulation of lung ciliated cell differentiation|
|regulation of lung ciliated cell differentiation|
|positive regulation of connective tissue growth factor production|
|regulation of connective tissue growth factor production|
|regulation of pancreatic stellate cell proliferation|
|negative regulation of complement-dependent cytotoxicity|
|negative regulation of NAD(P)H oxidase activity|
|negative regulation of transforming growth factor beta production|
|regulation of NAD(P)H oxidase activity|
|regulation of complement-dependent cytotoxicity|
|positive regulation of mast cell activation involved in immune response|
|positive regulation of mast cell degranulation|
|positive regulation of mast cell activation|
|regulation of proton transport|
|negative regulation of cell killing|
|negative regulation of oxidoreductase activity|
|positive regulation of macrophage activation|
|positive regulation of leukocyte degranulation|
|negative regulation of endothelial cell apoptotic process|
|microglial cell activation|
|leukocyte activation involved in inflammatory response|
|positive regulation of myeloid leukocyte mediated immunity|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|regulation of transforming growth factor beta production|
|glial cell activation|
|positive regulation of release of sequestered calcium ion into cytosol|
|negative regulation of epithelial cell differentiation|
|positive regulation of B cell proliferation|
|neuroinflammatory response|
|negative regulation of epithelial cell apoptotic process|
|positive regulation of immunoglobulin production|
|regulation of mast cell activation|
|regulation of leukocyte degranulation|
|response to nicotine|
|positive regulation of fibroblast proliferation|
|macrophage activation|
|regulation of endothelial cell apoptotic process|
|regulation of macrophage activation|
|positive regulation of regulated secretory pathway|
|positive regulation of calcium ion transport into cytosol|
|regulation of myeloid leukocyte mediated immunity|
|positive regulation of epithelial cell differentiation|
|regulation of B cell proliferation|
|regulation of immunoglobulin production|
|positive regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of calcium ion transmembrane transport|
|regulation of release of sequestered calcium ion into cytosol|
|cellular response to mechanical stimulus|
|regulation of tyrosine phosphorylation of STAT protein|
|regulation of epithelial cell apoptotic process|
|regulation of fibroblast proliferation|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of exocytosis|
|regulation of oxidoreductase activity|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of cold-induced thermogenesis|
|regulation of calcium ion transport into cytosol|
|regulation of cell killing|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|response to ethanol|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|regulation of smooth muscle cell proliferation|
|regulation of receptor signaling pathway via STAT|
|positive regulation of leukocyte proliferation|
|regulation of production of molecular mediator of immune response|
|positive regulation of cation transmembrane transport|
|regulation of epithelial cell differentiation|
|regulation of cold-induced thermogenesis|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|regulation of regulated secretory pathway|
|positive regulation of B cell activation|
|cytokine activity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of transmembrane transport|
|regulation of leukocyte mediated immunity|
|negative regulation of neuron death|
|positive regulation of intracellular transport|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|response to mechanical stimulus|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|regulation of exocytosis|
|response to alcohol|
|regulation of calcium ion transport|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|response to antibiotic|
|regulation of neuron death|
|response to lipopolysaccharide|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|cellular response to external stimulus|
|regulation of intracellular transport|
|positive regulation of lymphocyte activation|
|regulation of metal ion transport|
|external side of plasma membrane|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|positive regulation of cytokine production|
|calcium ion homeostasis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|regulation of immune effector process|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|inflammatory response|
|response to toxic substance|
|regulation of lymphocyte activation|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|metal ion homeostasis|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of cytokine production|
|regulation of ion transport|
|cation homeostasis|
|regulation of protein transport|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of secretion|
|response to lipid|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|leukocyte activation|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|positive regulation of transport|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|response to drug|
|regulation of protein localization|
|positive regulation of phosphorylation|
|cell activation|
|response to cytokine|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|extracellular region|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17003
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL13 Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>