======= IL18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL18
  * **<color #00a2e8>Official Name</color>**: interleukin 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3606|3606]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14116|Q14116]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600953|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|granulocyte macrophage colony-stimulating factor biosynthetic process|
|chemokine metabolic process|
|interleukin-18 receptor binding|
|chemokine biosynthetic process|
|interleukin-13 biosynthetic process|
|interferon-gamma biosynthetic process|
|granulocyte macrophage colony-stimulating factor production|
|interleukin-2 biosynthetic process|
|interleukin-13 production|
|T-helper 1 cell cytokine production|
|positive regulation of NK T cell proliferation|
|regulation of NK T cell proliferation|
|regulation of T-helper 1 cell cytokine production|
|positive regulation of T-helper 1 cell cytokine production|
|positive regulation of T-helper 2 cell differentiation|
|cellular response to interleukin-18|
|positive regulation of natural killer cell proliferation|
|interleukin-18-mediated signaling pathway|
|CD4-positive, alpha-beta T cell cytokine production|
|positive regulation of NK T cell activation|
|type 2 immune response|
|regulation of natural killer cell proliferation|
|chemokine production|
|interleukin-2 production|
|response to interleukin-18|
|regulation of NK T cell activation|
|T cell cytokine production|
|regulation of T-helper 2 cell differentiation|
|interleukin-6 production|
|positive regulation of granulocyte macrophage colony-stimulating factor production|
|positive regulation of neuroinflammatory response|
|sleep|
|cytokine biosynthetic process|
|cytokine metabolic process|
|regulation of granulocyte macrophage colony-stimulating factor production|
|positive regulation of type 2 immune response|
|positive regulation of macrophage derived foam cell differentiation|
|positive regulation of interleukin-17 production|
|positive regulation of alpha-beta T cell proliferation|
|interferon-gamma production|
|positive regulation of T cell cytokine production|
|T-helper 1 type immune response|
|positive regulation of T-helper 1 type immune response|
|positive regulation of natural killer cell activation|
|positive regulation of T-helper cell differentiation|
|positive regulation of activated T cell proliferation|
|cytokine production involved in immune response|
|negative regulation of myoblast differentiation|
|natural killer cell mediated cytotoxicity|
|regulation of T-helper 1 type immune response|
|natural killer cell mediated immunity|
|regulation of macrophage derived foam cell differentiation|
|regulation of interleukin-17 production|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of type 2 immune response|
|regulation of alpha-beta T cell proliferation|
|regulation of neuroinflammatory response|
|positive regulation of tissue remodeling|
|regulation of T cell cytokine production|
|activation of protein kinase B activity|
|regulation of natural killer cell activation|
|lipopolysaccharide-mediated signaling pathway|
|regulation of T-helper cell differentiation|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|acylglycerol homeostasis|
|triglyceride homeostasis|
|regulation of activated T cell proliferation|
|leukocyte mediated cytotoxicity|
|T cell mediated immunity|
|positive regulation of alpha-beta T cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of T cell mediated immunity|
|regulation of myoblast differentiation|
|positive regulation of cytokine production involved in immune response|
|natural killer cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|positive regulation of interferon-gamma production|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of T cell mediated immunity|
|regulation of tissue remodeling|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of tyrosine phosphorylation of STAT protein|
|cholesterol homeostasis|
|sterol homeostasis|
|positive regulation of T cell differentiation|
|positive regulation of receptor signaling pathway via JAK-STAT|
|regulation of cytokine production involved in immune response|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of receptor signaling pathway via STAT|
|cell killing|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|positive regulation of T cell proliferation|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of cold-induced thermogenesis|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|regulation of NIK/NF-kappaB signaling|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of lymphocyte proliferation|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of mononuclear cell proliferation|
|regulation of smooth muscle cell proliferation|
|lipid homeostasis|
|positive regulation of leukocyte mediated immunity|
|regulation of receptor signaling pathway via STAT|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|positive regulation of inflammatory response|
|regulation of production of molecular mediator of immune response|
|regulation of cold-induced thermogenesis|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|regulation of lymphocyte mediated immunity|
|cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|positive regulation of protein kinase B signaling|
|regulation of lymphocyte differentiation|
|cytokine activity|
|production of molecular mediator of immune response|
|cellular response to lipopolysaccharide|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular response to molecule of bacterial origin|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of protein kinase B signaling|
|regulation of leukocyte proliferation|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|positive regulation of DNA-binding transcription factor activity|
|lymphocyte mediated immunity|
|regulation of leukocyte differentiation|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of leukocyte cell-cell adhesion|
|response to lipopolysaccharide|
|regulation of T cell activation|
|angiogenesis|
|response to molecule of bacterial origin|
|activation of protein kinase activity|
|regulation of inflammatory response|
|positive regulation of lymphocyte activation|
|MAPK cascade|
|lymphocyte activation|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|positive regulation of cell activation|
|regulation of DNA-binding transcription factor activity|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of immune effector process|
|positive regulation of defense response|
|blood vessel development|
|inflammatory response|
|neutrophil activation|
|granulocyte activation|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|cellular response to lipid|
|positive regulation of protein kinase activity|
|cellular response to organic cyclic compound|
|cell population proliferation|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|adaptive immune response|
|regulation of cell activation|
|tube morphogenesis|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|negative regulation of cell differentiation|
|regulation of defense response|
|innate immune response|
|leukocyte mediated immunity|
|regulation of protein kinase activity|
|tube development|
|response to lipid|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|leukocyte activation|
|negative regulation of developmental process|
|defense response to other organism|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8400
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL18 Expression in NALM6 Cells: 1.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>