======= IL21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL21
  * **<color #00a2e8>Official Name</color>**: interleukin 21
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=59067|59067]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HBE4|Q9HBE4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605384|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. {ECO:0000250, ECO:0000269|PubMed:11081504, ECO:0000269|PubMed:15178704}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL15|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-2 receptor binding|
|cellular response to interleukin-21|
|interleukin-21-mediated signaling pathway|
|response to interleukin-21|
|tyrosine phosphorylation of STAT protein|
|cytokine receptor binding|
|positive regulation of interferon-gamma biosynthetic process|
|regulation of interferon-gamma biosynthetic process|
|positive regulation of interleukin-17 production|
|regulation of interleukin-17 production|
|positive regulation of natural killer cell mediated cytotoxicity|
|positive regulation of tissue remodeling|
|positive regulation of natural killer cell mediated immunity|
|receptor signaling pathway via JAK-STAT|
|receptor signaling pathway via STAT|
|positive regulation of B cell proliferation|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|positive regulation of leukocyte mediated cytotoxicity|
|regulation of B cell proliferation|
|positive regulation of interferon-gamma production|
|positive regulation of cell killing|
|positive regulation of cytokine biosynthetic process|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of tissue remodeling|
|regulation of leukocyte mediated cytotoxicity|
|regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of T cell proliferation|
|regulation of interferon-gamma production|
|regulation of cell killing|
|regulation of cytokine biosynthetic process|
|positive regulation of lymphocyte mediated immunity|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|regulation of receptor signaling pathway via STAT|
|positive regulation of leukocyte proliferation|
|positive regulation of inflammatory response|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|regulation of lymphocyte mediated immunity|
|regulation of T cell proliferation|
|cell maturation|
|positive regulation of B cell activation|
|cytokine activity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|developmental maturation|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|positive regulation of cytokine production|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of defense response|
|regulation of multi-organism process|
|positive regulation of immune response|
|peptidyl-amino acid modification|
|positive regulation of cell population proliferation|
|protein phosphorylation|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15999
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL21 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>