======= IL23A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL23A
  * **<color #00a2e8>Official Name</color>**: interleukin 23 subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51561|51561]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPF7|Q9NPF7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL23A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL23A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605580|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:16424222}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-23 complex|
|interleukin-23 receptor binding|
|positive regulation of T-helper 17 cell lineage commitment|
|positive regulation of NK T cell proliferation|
|regulation of NK T cell proliferation|
|regulation of T-helper 17 cell lineage commitment|
|positive regulation of memory T cell differentiation|
|positive regulation of natural killer cell proliferation|
|positive regulation of activation of Janus kinase activity|
|positive regulation of NK T cell activation|
|positive regulation of T-helper 17 cell differentiation|
|regulation of natural killer cell proliferation|
|regulation of activation of Janus kinase activity|
|positive regulation of cell fate commitment|
|regulation of memory T cell differentiation|
|interleukin-23-mediated signaling pathway|
|positive regulation of T-helper 17 type immune response|
|regulation of NK T cell activation|
|positive regulation of granulocyte macrophage colony-stimulating factor production|
|regulation of granulocyte macrophage colony-stimulating factor production|
|regulation of T-helper 17 cell differentiation|
|positive regulation of interleukin-17 production|
|negative regulation of interleukin-10 production|
|positive regulation of alpha-beta T cell proliferation|
|regulation of T-helper 17 type immune response|
|positive regulation of natural killer cell activation|
|positive regulation of T-helper 1 type immune response|
|positive regulation of T-helper cell differentiation|
|positive regulation of activated T cell proliferation|
|positive regulation of neutrophil chemotaxis|
|positive regulation of T cell mediated cytotoxicity|
|positive regulation of defense response to virus by host|
|positive regulation of osteoclast differentiation|
|positive regulation of granulocyte chemotaxis|
|regulation of T-helper 1 type immune response|
|regulation of cell fate commitment|
|regulation of interleukin-17 production|
|positive regulation of neutrophil migration|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of neutrophil chemotaxis|
|regulation of alpha-beta T cell proliferation|
|positive regulation of tissue remodeling|
|regulation of natural killer cell activation|
|regulation of T cell mediated cytotoxicity|
|regulation of T-helper cell differentiation|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of interleukin-12 production|
|regulation of neutrophil migration|
|regulation of activated T cell proliferation|
|positive regulation of interleukin-10 production|
|regulation of defense response to virus by host|
|T cell proliferation|
|regulation of granulocyte chemotaxis|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of alpha-beta T cell differentiation|
|positive regulation of T cell mediated immunity|
|regulation of interleukin-10 production|
|regulation of interleukin-12 production|
|positive regulation of leukocyte mediated cytotoxicity|
|positive regulation of myeloid leukocyte differentiation|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|positive regulation of interferon-gamma production|
|regulation of osteoclast differentiation|
|positive regulation of cell killing|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of T cell mediated immunity|
|regulation of defense response to virus|
|regulation of tissue remodeling|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of leukocyte mediated cytotoxicity|
|regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of T cell differentiation|
|lymphocyte proliferation|
|defense response to Gram-negative bacterium|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of tumor necrosis factor production|
|mononuclear cell proliferation|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of leukocyte chemotaxis|
|positive regulation of myeloid cell differentiation|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|positive regulation of T cell proliferation|
|leukocyte proliferation|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|tissue remodeling|
|regulation of cell killing|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|regulation of NIK/NF-kappaB signaling|
|regulation of leukocyte chemotaxis|
|regulation of myeloid leukocyte differentiation|
|positive regulation of leukocyte migration|
|positive regulation of lymphocyte proliferation|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|regulation of receptor signaling pathway via STAT|
|positive regulation of chemotaxis|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|positive regulation of inflammatory response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|regulation of lymphocyte mediated immunity|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|regulation of lymphocyte differentiation|
|cytokine activity|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|defense response to virus|
|regulation of leukocyte migration|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of chemotaxis|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|regulation of myeloid cell differentiation|
|T cell activation|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|response to virus|
|regulation of leukocyte cell-cell adhesion|
|endoplasmic reticulum lumen|
|regulation of T cell activation|
|defense response to bacterium|
|regulation of inflammatory response|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of immune effector process|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cell population proliferation|
|positive regulation of kinase activity|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|regulation of cell activation|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of kinase activity|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|defense response to other organism|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13720
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL23A Expression in NALM6 Cells: 0.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>