======= IL33 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL33
  * **<color #00a2e8>Official Name</color>**: interleukin 33
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90865|90865]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95760|O95760]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL33&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL33|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608678|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). {ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:17853410, ECO:0000269|PubMed:18836528}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-33-mediated signaling pathway|
|negative regulation of immunoglobulin secretion|
|microglial cell activation involved in immune response|
|macrophage proliferation|
|negative regulation of T-helper 1 type immune response|
|microglial cell proliferation|
|negative regulation of immunoglobulin production|
|positive regulation of immunoglobulin secretion|
|macrophage activation involved in immune response|
|positive regulation of interleukin-5 production|
|positive regulation of neuroinflammatory response|
|positive regulation of interleukin-13 production|
|positive regulation of chemokine secretion|
|glial cell proliferation|
|regulation of chemokine secretion|
|positive regulation of type 2 immune response|
|regulation of immunoglobulin secretion|
|regulation of interleukin-5 production|
|regulation of interleukin-13 production|
|positive regulation of interleukin-4 production|
|positive regulation of macrophage activation|
|regulation of interleukin-4 production|
|regulation of T-helper 1 type immune response|
|regulation of type 2 immune response|
|leukocyte activation involved in inflammatory response|
|microglial cell activation|
|regulation of neuroinflammatory response|
|negative regulation of interferon-gamma production|
|negative regulation of production of molecular mediator of immune response|
|glial cell activation|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|neuroinflammatory response|
|positive regulation of immunoglobulin production|
|negative regulation of leukocyte migration|
|negative regulation of adaptive immune response|
|macrophage activation|
|regulation of macrophage activation|
|positive regulation of chemokine production|
|regulation of immunoglobulin production|
|regulation of chemokine production|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|transport vesicle|
|positive regulation of interleukin-6 production|
|extrinsic apoptotic signaling pathway|
|positive regulation of production of molecular mediator of immune response|
|leukocyte proliferation|
|positive regulation of ubiquitin-dependent protein catabolic process|
|regulation of interferon-gamma production|
|positive regulation of proteasomal protein catabolic process|
|negative regulation of immune effector process|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|chromosome|
|negative regulation of protein secretion|
|positive regulation of cytokine secretion|
|negative regulation of peptide secretion|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|positive regulation of cellular protein catabolic process|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of immune response|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of adaptive immune response|
|cytokine activity|
|negative regulation of protein transport|
|regulation of proteasomal protein catabolic process|
|negative regulation of establishment of protein localization|
|defense response to virus|
|regulation of leukocyte migration|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|gliogenesis|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|positive regulation of immune effector process|
|negative regulation of secretion|
|regulation of cellular protein catabolic process|
|negative regulation of cell migration|
|positive regulation of protein secretion|
|negative regulation of cell motility|
|negative regulation of cytokine production|
|response to virus|
|protein deubiquitination|
|apoptotic signaling pathway|
|positive regulation of peptide secretion|
|protein modification by small protein removal|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of inflammatory response|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of catabolic process|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|negative regulation of transport|
|regulation of peptide secretion|
|inflammatory response|
|myeloid cell activation involved in immune response|
|cell population proliferation|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|regulation of cellular catabolic process|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of cell motility|
|apoptotic process|
|leukocyte activation|
|defense response to other organism|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|programmed cell death|
|cell activation|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15801
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL33 Expression in NALM6 Cells: 0.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>