======= IL4 =======
== Gene Information ==
* **Official Symbol**: IL4
* **Official Name**: interleukin 4
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3565|3565]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P05112|P05112]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=IL4&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL4|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/147780|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
* **UniProt Summary**: Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). {ECO:0000250|UniProtKB:P07750, ECO:0000269|PubMed:3016727}.
|IL4|
|connective tissue growth factor production|
|connective tissue growth factor biosynthetic process|
|T-helper 2 cell cytokine production|
|negative regulation of complement-dependent cytotoxicity|
|interleukin-4 receptor binding|
|positive regulation of isotype switching to IgE isotypes|
|activation of Janus kinase activity|
|regulation of isotype switching to IgE isotypes|
|CD4-positive, alpha-beta T cell cytokine production|
|negative regulation of tumor necrosis factor biosynthetic process|
|positive regulation of amyloid-beta clearance|
|type 2 immune response|
|positive regulation of cellular respiration|
|T cell cytokine production|
|positive regulation of MHC class II biosynthetic process|
|positive regulation of isotype switching to IgG isotypes|
|regulation of complement-dependent cytotoxicity|
|regulation of isotype switching to IgG isotypes|
|positive regulation of ATP biosynthetic process|
|negative regulation of neuroinflammatory response|
|cytokine biosynthetic process|
|regulation of MHC class II biosynthetic process|
|positive regulation of interleukin-13 production|
|cytokine metabolic process|
|regulation of amyloid-beta clearance|
|regulation of ATP biosynthetic process|
|myeloid dendritic cell differentiation|
|cytokine production involved in immune response|
|positive regulation of nucleotide biosynthetic process|
|myeloid dendritic cell activation|
|regulation of interleukin-13 production|
|negative regulation of cell killing|
|positive regulation of purine nucleotide biosynthetic process|
|positive regulation of isotype switching|
|negative regulation of osteoclast differentiation|
|regulation of tumor necrosis factor biosynthetic process|
|regulation of cellular respiration|
|negative regulation of endothelial cell apoptotic process|
|negative regulation of cytokine biosynthetic process|
|regulation of neuroinflammatory response|
|dendritic cell differentiation|
|regulation of isotype switching|
|positive regulation of B cell mediated immunity|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of DNA recombination|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|positive regulation of B cell proliferation|
|neuroinflammatory response|
|negative regulation of epithelial cell apoptotic process|
|T cell mediated immunity|
|positive regulation of immunoglobulin production|
|positive regulation of nucleotide metabolic process|
|positive regulation of ATP metabolic process|
|positive regulation of purine nucleotide metabolic process|
|negative regulation of myeloid leukocyte differentiation|
|regulation of endothelial cell apoptotic process|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|positive regulation of receptor-mediated endocytosis|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|regulation of B cell proliferation|
|regulation of immunoglobulin production|
|regulation of osteoclast differentiation|
|negative regulation of epithelial cell migration|
|positive regulation of macroautophagy|
|positive regulation of tyrosine phosphorylation of STAT protein|
|negative regulation of myeloid cell differentiation|
|regulation of epithelial cell apoptotic process|
|regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of T cell differentiation|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of lymphocyte differentiation|
|positive regulation of T cell proliferation|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of cold-induced thermogenesis|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|negative regulation of leukocyte differentiation|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|regulation of DNA recombination|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|regulation of cytokine biosynthetic process|
|B cell differentiation|
|myeloid leukocyte differentiation|
|regulation of myeloid leukocyte differentiation|
|regulation of purine nucleotide metabolic process|
|cholesterol metabolic process|
|regulation of nucleotide metabolic process|
|positive regulation of autophagy|
|regulation of ATP metabolic process|
|secondary alcohol metabolic process|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|sterol metabolic process|
|regulation of receptor signaling pathway via STAT|
|negative regulation of hemopoiesis|
|negative regulation of inflammatory response|
|positive regulation of leukocyte proliferation|
|positive regulation of small molecule metabolic process|
|regulation of T cell differentiation|
|regulation of production of molecular mediator of immune response|
|regulation of cold-induced thermogenesis|
|peptidyl-tyrosine phosphorylation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|peptidyl-tyrosine modification|
|regulation of tumor necrosis factor production|
|cytokine production|
|regulation of lymphocyte mediated immunity|
|regulation of tumor necrosis factor superfamily cytokine production|
|B cell activation|
|regulation of T cell proliferation|
|regulation of generation of precursor metabolites and energy|
|regulation of adaptive immune response|
|growth factor activity|
|positive regulation of B cell activation|
|regulation of lymphocyte differentiation|
|regulation of macroautophagy|
|cytokine activity|
|production of molecular mediator of immune response|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of DNA metabolic process|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of endocytosis|
|negative regulation of defense response|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|myeloid cell differentiation|
|regulation of epithelial cell migration|
|regulation of leukocyte proliferation|
|regulation of myeloid cell differentiation|
|T cell activation|
|lymphocyte differentiation|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|negative regulation of cell migration|
|steroid metabolic process|
|lymphocyte mediated immunity|
|regulation of leukocyte differentiation|
|negative regulation of cell motility|
|negative regulation of cytokine production|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of leukocyte cell-cell adhesion|
|negative regulation of cellular component movement|
|alcohol metabolic process|
|regulation of T cell activation|
|negative regulation of locomotion|
|activation of protein kinase activity|
|leukocyte differentiation|
|regulation of autophagy|
|regulation of inflammatory response|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|negative regulation of response to external stimulus|
|positive regulation of cellular catabolic process|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|organic hydroxy compound metabolic process|
|regulation of immune effector process|
|inflammatory response|
|regulation of lymphocyte activation|
|positive regulation of protein kinase activity|
|regulation of vesicle-mediated transport|
|hemopoiesis|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|regulation of cell activation|
|immune system development|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cytokine production|
|negative regulation of cell differentiation|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|negative regulation of RNA metabolic process|
|defense response|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.83|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.14|
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 17192
* **Expression level (log2 read counts)**: -6.6
{{:chemogenomics:nalm6 dist.png?nolink |}}