======= IL4R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL4R
  * **<color #00a2e8>Official Name</color>**: interleukin 4 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3566|3566]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P24394|P24394]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL4R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL4R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147781|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL4Ra N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-4 receptor activity|
|negative regulation of T-helper 1 cell differentiation|
|interleukin-4-mediated signaling pathway|
|response to odorant|
|negative regulation of T-helper 1 type immune response|
|positive regulation of T-helper 2 cell differentiation|
|regulation of T-helper 1 cell differentiation|
|regulation of T-helper 2 cell differentiation|
|positive regulation of mast cell degranulation|
|positive regulation of chemokine secretion|
|positive regulation of mast cell activation involved in immune response|
|negative regulation of T-helper cell differentiation|
|positive regulation of type 2 immune response|
|production of molecular mediator involved in inflammatory response|
|regulation of chemokine secretion|
|ovulation|
|positive regulation of myoblast fusion|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of mast cell activation|
|regulation of myoblast fusion|
|positive regulation of T-helper cell differentiation|
|defense response to protozoan|
|response to protozoan|
|negative regulation of alpha-beta T cell differentiation|
|positive regulation of leukocyte degranulation|
|positive regulation of macrophage activation|
|regulation of T-helper 1 type immune response|
|positive regulation of syncytium formation by plasma membrane fusion|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|cellular response to interleukin-4|
|regulation of syncytium formation by plasma membrane fusion|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of type 2 immune response|
|response to interleukin-4|
|positive regulation of myeloid leukocyte mediated immunity|
|positive regulation of myotube differentiation|
|regulation of T-helper cell differentiation|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|negative regulation of alpha-beta T cell activation|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of immunoglobulin production|
|negative regulation of T cell differentiation|
|regulation of mast cell activation|
|negative regulation of adaptive immune response|
|positive regulation of alpha-beta T cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of leukocyte degranulation|
|regulation of macrophage activation|
|negative regulation of lymphocyte differentiation|
|positive regulation of regulated secretory pathway|
|positive regulation of chemokine production|
|regulation of myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|regulation of myeloid leukocyte mediated immunity|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|regulation of immunoglobulin production|
|response to estrogen|
|regulation of chemokine production|
|positive regulation of T cell differentiation|
|positive regulation of muscle cell differentiation|
|positive regulation of exocytosis|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of cold-induced thermogenesis|
|negative regulation of leukocyte differentiation|
|regulation of striated muscle cell differentiation|
|negative regulation of T cell activation|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|female gamete generation|
|positive regulation of leukocyte mediated immunity|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|positive regulation of cytokine secretion|
|regulation of production of molecular mediator of immune response|
|regulation of cold-induced thermogenesis|
|negative regulation of lymphocyte activation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|regulation of muscle cell differentiation|
|regulation of adaptive immune response|
|regulation of regulated secretory pathway|
|regulation of lymphocyte differentiation|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|positive regulation of hemopoiesis|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|regulation of cytokine secretion|
|receptor complex|
|regulation of leukocyte mediated immunity|
|immunoglobulin mediated immune response|
|positive regulation of intracellular transport|
|B cell mediated immunity|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of exocytosis|
|positive regulation of cell-cell adhesion|
|lymphocyte mediated immunity|
|positive regulation of protein secretion|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of peptide secretion|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of intracellular transport|
|positive regulation of lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|regulation of peptide secretion|
|inflammatory response|
|regulation of lymphocyte activation|
|regulation of vesicle-mediated transport|
|regulation of leukocyte activation|
|adaptive immune response|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|gamete generation|
|regulation of cytokine production|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|leukocyte mediated immunity|
|regulation of secretion|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|positive regulation of immune response|
|regulation of cellular localization|
|negative regulation of developmental process|
|defense response to other organism|
|positive regulation of cell differentiation|
|positive regulation of transport|
|multi-organism reproductive process|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|immune effector process|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14393
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL4R Expression in NALM6 Cells: 4.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>