======= IMMP2L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IMMP2L
  * **<color #00a2e8>Official Name</color>**: inner mitochondrial membrane peptidase subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83943|83943]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96T52|Q96T52]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IMMP2L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IMMP2L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605977|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. {ECO:0000269|PubMed:15814844}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase S24|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cerebellum vasculature development|
|mitochondrial inner membrane peptidase complex|
|protein processing involved in protein targeting to mitochondrion|
|mitochondrial protein processing|
|signal peptide processing|
|ovulation|
|superoxide metabolic process|
|ovarian follicle development|
|protein targeting to mitochondrion|
|serine-type peptidase activity|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|peptidase activity|
|female gonad development|
|development of primary female sexual characteristics|
|mitochondrial respiratory chain complex assembly|
|female sex differentiation|
|respiratory electron transport chain|
|reactive oxygen species metabolic process|
|female gamete generation|
|protein processing|
|cellular respiration|
|electron transport chain|
|gonad development|
|mitochondrial transport|
|development of primary sexual characteristics|
|protein maturation|
|energy derivation by oxidation of organic compounds|
|sex differentiation|
|protein targeting|
|blood circulation|
|circulatory system process|
|generation of precursor metabolites and energy|
|reproductive structure development|
|reproductive system development|
|establishment of protein localization to organelle|
|mitochondrion organization|
|vasculature development|
|cardiovascular system development|
|peptide metabolic process|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|protein localization to organelle|
|brain development|
|cellular response to DNA damage stimulus|
|head development|
|cellular amide metabolic process|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|circulatory system development|
|oxidation-reduction process|
|central nervous system development|
|intracellular protein transport|
|multi-organism reproductive process|
|proteolysis|
|reproductive process|
|reproduction|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16255
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IMMP2L Expression in NALM6 Cells: 2.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>