======= INCENP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INCENP
  * **<color #00a2e8>Official Name</color>**: inner centromere protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3619|3619]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQS7|Q9NQS7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INCENP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INCENP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604411|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|INCENP ARK-bind|
|INCENP N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of mitotic cytokinesis|
|central element|
|chromocenter|
|lateral element|
|pericentric heterochromatin|
|chromosome, centromeric region|
|mitotic cytokinesis|
|kinetochore|
|regulation of cytokinesis|
|condensed chromosome kinetochore|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|mitotic sister chromatid segregation|
|spindle|
|sister chromatid segregation|
|mitotic nuclear division|
|midbody|
|regulation of cell division|
|nuclear chromosome segregation|
|chromosome segregation|
|nuclear body|
|nuclear division|
|organelle fission|
|microtubule|
|cell division|
|protein-containing complex|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|regulation of cell cycle process|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.91|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.75|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.44|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.34|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-2.33|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.29|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.04|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.9|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.8|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.75|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.72|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.77|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.79|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.96|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.01|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrp7a|RRP7A]]|0.48|
|[[:human genes:a:aurkb|AURKB]]|0.471|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.455|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.454|
|[[:human genes:p:pole|POLE]]|0.434|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.415|
|[[:human genes:b:bysl|BYSL]]|0.41|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.404|
|[[:human genes:t:tfip11|TFIP11]]|0.404|
|[[:human genes:r:rps5|RPS5]]|0.403|
|[[:human genes:r:rps11|RPS11]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 588/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|25/28|
|blood|22/28|
|bone|19/25|
|breast|22/33|
|central nervous system|47/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|13/15|
|kidney|17/21|
|liver|18/20|
|lung|58/75|
|lymphocyte|12/14|
|ovary|22/26|
|pancreas|20/24|
|peripheral nervous system|13/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|6/7|
|thyroid|1/2|
|upper aerodigestive|18/22|
|urinary tract|20/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 69
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INCENP Expression in NALM6 Cells: 7.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>