======= INO80 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INO80
  * **<color #00a2e8>Official Name</color>**: INO80 complex ATPase subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54617|54617]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULG1|Q9ULG1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INO80&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INO80|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610169|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle. {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897, ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNF2 N|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleosome mobilization|
|positive regulation of nuclear cell cycle DNA replication|
|positive regulation of DNA-dependent DNA replication|
|UV-damage excision repair|
|Ino80 complex|
|regulation of nuclear cell cycle DNA replication|
|3-5 DNA helicase activity|
|positive regulation of DNA replication|
|alpha-tubulin binding|
|DNA-dependent ATPase activity|
|intermediate filament cytoskeleton|
|regulation of DNA-dependent DNA replication|
|cellular response to ionizing radiation|
|ATP-dependent chromatin remodeling|
|cellular response to UV|
|double-strand break repair via homologous recombination|
|recombinational repair|
|spindle assembly|
|mitotic sister chromatid segregation|
|regulation of DNA replication|
|DNA duplex unwinding|
|cellular response to light stimulus|
|spindle|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|DNA geometric change|
|regulation of DNA-templated transcription in response to stress|
|histone binding|
|sister chromatid segregation|
|response to UV|
|mitotic nuclear division|
|response to ionizing radiation|
|regulation of G1/S transition of mitotic cell cycle|
|spindle organization|
|nucleosome organization|
|chromatin remodeling|
|positive regulation of cell growth|
|regulation of cell cycle G1/S phase transition|
|cellular response to radiation|
|double-strand break repair|
|nuclear chromosome segregation|
|DNA recombination|
|ATPase activity|
|protein-DNA complex subunit organization|
|positive regulation of growth|
|actin binding|
|chromosome segregation|
|protein deubiquitination|
|nuclear body|
|nuclear division|
|positive regulation of cell cycle process|
|protein modification by small protein removal|
|DNA conformation change|
|response to light stimulus|
|organelle fission|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|microtubule|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|response to radiation|
|regulation of cell cycle phase transition|
|microtubule cytoskeleton organization|
|cell division|
|DNA repair|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of growth|
|microtubule-based process|
|mitotic cell cycle|
|chromatin organization|
|DNA metabolic process|
|regulation of cell cycle process|
|organelle assembly|
|cellular response to DNA damage stimulus|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|cytoskeleton organization|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|proteolysis|
|organic cyclic compound biosynthetic process|
|cell cycle|
|DNA binding|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.2|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.19|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.02|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.94|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.89|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.76|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.86|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.87|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.88|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:uchl5|UCHL5]]|0.543|
|[[:human genes:a:actr5|ACTR5]]|0.513|
|[[:human genes:i:ino80b|INO80B]]|0.491|
|[[:human genes:n:nfrkb|NFRKB]]|0.49|
|[[:human genes:i:ino80e|INO80E]]|0.473|
|[[:human genes:t:tfpt|TFPT]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1068
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INO80 Expression in NALM6 Cells: 6.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>