======= IRAK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IRAK3
  * **<color #00a2e8>Official Name</color>**: interleukin 1 receptor associated kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11213|11213]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y616|Q9Y616]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IRAK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IRAK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604459|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. {ECO:0000250|UniProtKB:Q8K4B2, ECO:0000269|PubMed:10383454}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Death|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of macrophage tolerance induction|
|positive regulation of macrophage tolerance induction|
|negative regulation of macrophage cytokine production|
|positive regulation of tolerance induction|
|response to peptidoglycan|
|regulation of macrophage cytokine production|
|negative regulation of interleukin-12 production|
|regulation of tolerance induction|
|negative regulation of cytokine production involved in immune response|
|MyD88-dependent toll-like receptor signaling pathway|
|negative regulation of production of molecular mediator of immune response|
|negative regulation of toll-like receptor signaling pathway|
|negative regulation of interleukin-6 production|
|response to exogenous dsRNA|
|response to dsRNA|
|regulation of interleukin-12 production|
|negative regulation of innate immune response|
|negative regulation of tumor necrosis factor production|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of response to cytokine stimulus|
|regulation of toll-like receptor signaling pathway|
|negative regulation of protein complex disassembly|
|negative regulation of MAP kinase activity|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of cytokine production involved in immune response|
|negative regulation of response to biotic stimulus|
|interleukin-1-mediated signaling pathway|
|toll-like receptor signaling pathway|
|regulation of protein complex disassembly|
|negative regulation of immune effector process|
|pattern recognition receptor signaling pathway|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of protein catabolic process|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|regulation of tumor necrosis factor production|
|negative regulation of immune response|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|negative regulation of DNA-binding transcription factor activity|
|regulation of cytokine-mediated signaling pathway|
|negative regulation of MAPK cascade|
|cellular response to interleukin-1|
|regulation of response to cytokine stimulus|
|protein autophosphorylation|
|response to interleukin-1|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|magnesium ion binding|
|negative regulation of protein kinase activity|
|innate immune response-activating signal transduction|
|negative regulation of kinase activity|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|negative regulation of cytokine production|
|negative regulation of transferase activity|
|response to virus|
|negative regulation of catabolic process|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|positive regulation of response to biotic stimulus|
|protein serine/threonine kinase activity|
|negative regulation of response to external stimulus|
|regulation of protein catabolic process|
|negative regulation of protein phosphorylation|
|regulation of DNA-binding transcription factor activity|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|protein heterodimerization activity|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|regulation of response to biotic stimulus|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of cytokine production|
|negative regulation of cellular component organization|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|response to organic cyclic compound|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17176
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.94 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IRAK3 Expression in NALM6 Cells: 0.94'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>