======= IREB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IREB2
  * **<color #00a2e8>Official Name</color>**: iron responsive element binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3658|3658]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48200|P48200]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IREB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IREB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147582|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aconitase|
|Aconitase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|iron-responsive element binding|
|aconitate hydratase activity|
|citrate metabolic process|
|protoporphyrinogen IX biosynthetic process|
|protoporphyrinogen IX metabolic process|
|translation repressor activity|
|tricarboxylic acid metabolic process|
|heme biosynthetic process|
|porphyrin-containing compound biosynthetic process|
|tetrapyrrole biosynthetic process|
|heme metabolic process|
|intestinal absorption|
|tricarboxylic acid cycle|
|porphyrin-containing compound metabolic process|
|4 iron, 4 sulfur cluster binding|
|osteoclast differentiation|
|pigment biosynthetic process|
|tetrapyrrole metabolic process|
|cellular iron ion homeostasis|
|pigment metabolic process|
|iron ion transport|
|digestive system process|
|aerobic respiration|
|iron ion homeostasis|
|erythrocyte homeostasis|
|post-embryonic development|
|antibiotic metabolic process|
|cellular transition metal ion homeostasis|
|myeloid cell homeostasis|
|myeloid leukocyte differentiation|
|digestion|
|transition metal ion transport|
|negative regulation of translation|
|transition metal ion homeostasis|
|negative regulation of cellular amide metabolic process|
|cellular respiration|
|homeostasis of number of cells|
|cofactor biosynthetic process|
|myeloid cell differentiation|
|energy derivation by oxidation of organic compounds|
|leukocyte differentiation|
|regulation of translation|
|regulation of cellular amide metabolic process|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|drug metabolic process|
|posttranscriptional regulation of gene expression|
|hemopoiesis|
|cellular metal ion homeostasis|
|hematopoietic or lymphoid organ development|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|immune system development|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|negative regulation of gene expression|
|small molecule metabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.62|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.6|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.45|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.38|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.29|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.03|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.01|
|[[:results:exp539|42°C R08 exp539]]|-1.83|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.77|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.77|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.12|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.38|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.76|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.517|
|[[:human genes:a:ankh|ANKH]]|0.429|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16626
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IREB2 Expression in NALM6 Cells: 7.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>