======= IRF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IRF1
  * **<color #00a2e8>Official Name</color>**: interferon regulatory factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3659|3659]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10914|P10914]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IRF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IRF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147575|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon- stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti- proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells. {ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:15509808, ECO:0000269|PubMed:17516545, ECO:0000269|PubMed:17942705, ECO:0000269|PubMed:18084608, ECO:0000269|PubMed:18497060, ECO:0000269|PubMed:18641303, ECO:0000269|PubMed:19404407, ECO:0000269|PubMed:19851330, ECO:0000269|PubMed:21389130, ECO:0000269|PubMed:22200613, ECO:0000269|PubMed:22367195}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IRF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of MyD88-dependent toll-like receptor signaling pathway|
|negative regulation of regulatory T cell differentiation|
|regulation of CD8-positive, alpha-beta T cell proliferation|
|positive regulation of interleukin-12 biosynthetic process|
|CD8-positive, alpha-beta T cell differentiation|
|regulation of interleukin-12 biosynthetic process|
|CD8-positive, alpha-beta T cell activation|
|regulation of CD8-positive, alpha-beta T cell activation|
|cellular response to interferon-beta|
|response to interferon-beta|
|regulation of alpha-beta T cell proliferation|
|regulation of regulatory T cell differentiation|
|positive regulation of interferon-beta production|
|positive regulation of interleukin-12 production|
|negative regulation of T cell differentiation|
|regulation of interferon-beta production|
|alpha-beta T cell differentiation|
|negative regulation of lymphocyte differentiation|
|regulation of interleukin-12 production|
|alpha-beta T cell activation|
|cellular response to type I interferon|
|type I interferon signaling pathway|
|positive regulation of cytokine biosynthetic process|
|regulation of toll-like receptor signaling pathway|
|response to type I interferon|
|interferon-gamma-mediated signaling pathway|
|positive regulation of type I interferon production|
|cellular response to mechanical stimulus|
|regulation of alpha-beta T cell activation|
|negative regulation of leukocyte differentiation|
|regulation of cytokine biosynthetic process|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of type I interferon production|
|T cell differentiation|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|negative regulation of lymphocyte activation|
|cell cycle arrest|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|cellular response to interferon-gamma|
|regulation of lymphocyte differentiation|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|response to interferon-gamma|
|defense response to virus|
|negative regulation of cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|response to mechanical stimulus|
|regulation of leukocyte proliferation|
|T cell activation|
|nuclear chromatin|
|lymphocyte differentiation|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|response to virus|
|blood coagulation|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of T cell activation|
|leukocyte differentiation|
|cellular response to external stimulus|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|wound healing|
|transcription by RNA polymerase II|
|regulation of body fluid levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|hemopoiesis|
|response to wounding|
|negative regulation of cell cycle|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|transcription, DNA-templated|
|regulation of cell activation|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|negative regulation of cell differentiation|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|apoptotic process|
|leukocyte activation|
|negative regulation of developmental process|
|defense response to other organism|
|cell cycle process|
|cellular response to cytokine stimulus|
|programmed cell death|
|cell activation|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|regulation of immune response|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|cell cycle|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.79|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.74|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.8|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.99|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.1|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.19|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.2|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.71|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|3.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slfn11|SLFN11]]|0.448|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13267
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IRF1 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>