======= IRGM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IRGM
  * **<color #00a2e8>Official Name</color>**: immunity related GTPase M
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=345611|345611]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A1A4Y4|A1A4Y4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IRGM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IRGM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608212|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity). {ECO:0000250, ECO:0000269|PubMed:16888103}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IIGP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein lipidation involved in autophagosome assembly|
|CAMKK-AMPK signaling cascade|
|calmodulin dependent kinase signaling pathway|
|BH3 domain binding|
|modulation by symbiont of host autophagy|
|positive regulation of interferon-gamma-mediated signaling pathway|
|positive regulation by symbiont of host autophagy|
|C-terminal protein lipidation|
|positive regulation of response to interferon-gamma|
|positive regulation of autophagosome maturation|
|nucleotide-binding oligomerization domain containing 2 signaling pathway|
|regulation of protein complex stability|
|regulation of autophagosome maturation|
|C-terminal protein amino acid modification|
|CARD domain binding|
|cellular response to interferon-beta|
|regulation of response to interferon-gamma|
|regulation of interferon-gamma-mediated signaling pathway|
|modulation by symbiont of host cellular process|
|nucleotide-binding oligomerization domain containing signaling pathway|
|phagocytic cup|
|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|
|response to interferon-beta|
|protein serine/threonine kinase activator activity|
|positive regulation of peptidyl-threonine phosphorylation|
|cellular response to virus|
|autophagosome membrane|
|cytoplasmic pattern recognition receptor signaling pathway|
|positive regulation of protein complex disassembly|
|modification by symbiont of host morphology or physiology|
|regulation of peptidyl-threonine phosphorylation|
|protein destabilization|
|positive regulation of cytokine-mediated signaling pathway|
|positive regulation of response to cytokine stimulus|
|autophagosome assembly|
|autophagosome organization|
|positive regulation of macroautophagy|
|phagocytic vesicle membrane|
|defense response to Gram-negative bacterium|
|protein lipidation|
|lipoprotein biosynthetic process|
|cell projection|
|positive regulation of peptidyl-serine phosphorylation|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of protein complex disassembly|
|lipoprotein metabolic process|
|positive regulation of autophagy|
|pattern recognition receptor signaling pathway|
|vacuole organization|
|regulation of peptidyl-serine phosphorylation|
|calcium-mediated signaling|
|modification of morphology or physiology of other organism|
|interaction with host|
|macroautophagy|
|regulation of cytokine-mediated signaling pathway|
|intracellular receptor signaling pathway|
|regulation of macroautophagy|
|regulation of response to cytokine stimulus|
|protein stabilization|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|cellular response to biotic stimulus|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|autophagy|
|process utilizing autophagic mechanism|
|response to virus|
|regulation of protein stability|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|GTPase activity|
|defense response to bacterium|
|regulation of autophagy|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|post-translational protein modification|
|positive regulation of cellular catabolic process|
|GTP binding|
|positive regulation of catabolic process|
|regulation of protein complex assembly|
|regulation of innate immune response|
|protein kinase binding|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|Golgi membrane|
|positive regulation of organelle organization|
|activation of immune response|
|positive regulation of transferase activity|
|response to bacterium|
|organelle assembly|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|endoplasmic reticulum membrane|
|defense response to other organism|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|Golgi apparatus|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|mitochondrion|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18285
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IRGM Expression in NALM6 Cells: 0.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>