======= IST1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IST1
  * **<color #00a2e8>Official Name</color>**: IST1 factor associated with ESCRT-III
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9798|9798]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53990|P53990]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IST1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IST1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616434|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ist1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|viral capsid secondary envelopment|
|MIT domain binding|
|abscission|
|exit from host cell|
|movement in host environment|
|movement in environment of other organism involved in symbiotic interaction|
|exit from host|
|viral release from host cell|
|ESCRT III complex disassembly|
|ESCRT complex disassembly|
|positive regulation of collateral sprouting|
|regulation of collateral sprouting|
|Flemming body|
|multivesicular body assembly|
|multivesicular body organization|
|endoplasmic reticulum-Golgi intermediate compartment|
|endosome organization|
|positive regulation of axonogenesis|
|azurophil granule lumen|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|regulation of extent of cell growth|
|chromatin|
|positive regulation of cell morphogenesis involved in differentiation|
|interaction with host|
|midbody|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|nuclear envelope|
|regulation of cell size|
|regulation of axonogenesis|
|viral life cycle|
|protein-containing complex disassembly|
|protein domain specific binding|
|positive regulation of growth|
|protein-containing complex binding|
|positive regulation of neuron projection development|
|vesicle organization|
|regulation of cell morphogenesis involved in differentiation|
|cadherin binding|
|regulation of developmental growth|
|positive regulation of proteolysis|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|cellular component disassembly|
|regulation of cell growth|
|endomembrane system organization|
|positive regulation of neurogenesis|
|neutrophil degranulation|
|regulation of cell morphogenesis|
|centrosome|
|neutrophil activation involved in immune response|
|cell division|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of anatomical structure size|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of nervous system development|
|positive regulation of cell development|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of neuron differentiation|
|regulation of growth|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|regulated exocytosis|
|regulation of cell projection organization|
|regulation of proteolysis|
|organelle assembly|
|leukocyte mediated immunity|
|symbiotic process|
|exocytosis|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|positive regulation of cell differentiation|
|cell cycle process|
|secretion by cell|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell activation|
|immune effector process|
|secretion|
|positive regulation of cellular component organization|
|locomotion|
|cell cycle|
|positive regulation of developmental process|
|protein transport|
|generation of neurons|
|peptide transport|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|neurogenesis|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.83|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11129
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IST1 Expression in NALM6 Cells: 7.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>