======= ITFG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITFG2
  * **<color #00a2e8>Official Name</color>**: integrin alpha FG-GAP repeat containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55846|55846]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969R8|Q969R8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITFG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITFG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617421|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. {ECO:0000269|PubMed:28199306}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|germinal center B cell differentiation|
|KICSTOR complex|
|mature B cell differentiation involved in immune response|
|negative regulation of TORC1 signaling|
|mature B cell differentiation|
|regulation of TORC1 signaling|
|cellular response to glucose starvation|
|cellular response to amino acid starvation|
|B cell activation involved in immune response|
|response to amino acid starvation|
|negative regulation of TOR signaling|
|regulation of TOR signaling|
|B cell differentiation|
|lymphocyte activation involved in immune response|
|cellular response to starvation|
|B cell activation|
|response to starvation|
|cellular response to nutrient levels|
|lymphocyte differentiation|
|cellular response to extracellular stimulus|
|lysosomal membrane|
|leukocyte differentiation|
|cellular response to external stimulus|
|lymphocyte activation|
|response to nutrient levels|
|negative regulation of intracellular signal transduction|
|response to extracellular stimulus|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|leukocyte activation|
|cell activation|
|immune effector process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of response to stimulus|
|cellular response to stress|
|regulation of intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-3.75|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-3.47|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.91|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.86|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.81|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.78|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.45|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.18|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.18|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.17|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2.15|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.1|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.99|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.95|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.89|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.87|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.85|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.82|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.78|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.76|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.76|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.74|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.74|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.72|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.71|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.73|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.73|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.77|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.77|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.85|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.89|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.89|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.14|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|2.21|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.23|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.44|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|3.65|
|[[:results:exp504|MK2206 4μM R08 exp504]]|4.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:szt2|SZT2]]|0.743|
|[[:human genes:n:nprl3|NPRL3]]|0.722|
|[[:human genes:n:nprl2|NPRL2]]|0.713|
|[[:human genes:c:c12orf66|C12orf66]]|0.709|
|[[:human genes:k:kptn|KPTN]]|0.703|
|[[:human genes:d:depdc5|DEPDC5]]|0.664|
|[[:human genes:s:sesn2|SESN2]]|0.611|
|[[:human genes:t:tsc2|TSC2]]|0.555|
|[[:human genes:t:tsc1|TSC1]]|0.54|
|[[:human genes:c:ccdc130|CCDC130]]|0.486|
|[[:human genes:p:pds5b|PDS5B]]|0.407|
|[[:human genes:b:bcl6|BCL6]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15940
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITFG2 Expression in NALM6 Cells: 5.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>