======= ITGA4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGA4
  * **<color #00a2e8>Official Name</color>**: integrin subunit alpha 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3676|3676]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13612|P13612]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGA4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGA4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/192975|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). {ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FG-GAP|
|Integrin alpha2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|clathrin-dependent extracellular exosome endocytosis|
|cell-cell adhesion in response to extracellular stimulus|
|integrin alpha4-beta7 complex|
|cell-matrix adhesion involved in ameboidal cell migration|
|negative regulation of protein homodimerization activity|
|positive regulation of leukocyte tethering or rolling|
|C-X3-C chemokine binding|
|cell-cell adhesion mediated by integrin|
|diapedesis|
|axonogenesis involved in innervation|
|protein antigen binding|
|regulation of leukocyte tethering or rolling|
|positive regulation of leukocyte adhesion to vascular endothelial cell|
|positive regulation of vascular endothelial cell proliferation|
|positive regulation of cellular extravasation|
|leukocyte tethering or rolling|
|regulation of leukocyte adhesion to vascular endothelial cell|
|positive regulation of endothelial cell apoptotic process|
|regulation of vascular endothelial cell proliferation|
|leukocyte adhesion to vascular endothelial cell|
|regulation of protein homodimerization activity|
|cell adhesion mediated by integrin|
|clathrin-dependent endocytosis|
|fibronectin binding|
|innervation|
|regulation of cellular extravasation|
|positive regulation of T cell migration|
|positive regulation of epithelial cell apoptotic process|
|coreceptor activity|
|heterotypic cell-cell adhesion|
|positive regulation of lymphocyte migration|
|cellular extravasation|
|cellular response to amyloid-beta|
|endodermal cell differentiation|
|regulation of T cell migration|
|receptor clustering|
|endoderm formation|
|response to amyloid-beta|
|regulation of endothelial cell apoptotic process|
|leukocyte cell-cell adhesion|
|substrate adhesion-dependent cell spreading|
|cell adhesion molecule binding|
|neuron projection extension|
|regulation of lymphocyte migration|
|endoderm development|
|regulation of epithelial cell apoptotic process|
|nerve development|
|localization within membrane|
|developmental cell growth|
|cell growth|
|integrin-mediated signaling pathway|
|positive regulation of endothelial cell proliferation|
|negative regulation of protein binding|
|B cell differentiation|
|formation of primary germ layer|
|developmental growth involved in morphogenesis|
|cell-matrix adhesion|
|positive regulation of leukocyte migration|
|growth cone|
|regulation of endothelial cell proliferation|
|B cell activation|
|gastrulation|
|negative regulation of binding|
|ameboidal-type cell migration|
|establishment of vesicle localization|
|cell-substrate adhesion|
|vesicle localization|
|positive regulation of epithelial cell proliferation|
|regulation of leukocyte migration|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of protein binding|
|lymphocyte differentiation|
|receptor-mediated endocytosis|
|positive regulation of cell-cell adhesion|
|cellular response to extracellular stimulus|
|regulation of leukocyte cell-cell adhesion|
|cellular response to peptide|
|leukocyte differentiation|
|regulation of epithelial cell proliferation|
|cellular response to external stimulus|
|extracellular matrix organization|
|establishment of organelle localization|
|axonogenesis|
|neuronal cell body|
|regulation of binding|
|leukocyte migration|
|lymphocyte activation|
|extracellular structure organization|
|developmental growth|
|growth|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|axon development|
|focal adhesion|
|cell morphogenesis involved in neuron differentiation|
|response to peptide|
|neuron projection morphogenesis|
|protein localization to membrane|
|plasma membrane bounded cell projection morphogenesis|
|protein heterodimerization activity|
|cell projection morphogenesis|
|positive regulation of cell migration|
|cell-cell adhesion|
|cell part morphogenesis|
|positive regulation of cell motility|
|response to extracellular stimulus|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|endocytosis|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|embryonic morphogenesis|
|organelle localization|
|protein-containing complex|
|cellular response to organonitrogen compound|
|hematopoietic or lymphoid organ development|
|cell surface|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|cellular response to nitrogen compound|
|neuron projection development|
|import into cell|
|regulation of cell adhesion|
|positive regulation of cell death|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|regulation of cell migration|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|cell migration|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|neuron differentiation|
|cellular response to oxygen-containing compound|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|cellular response to endogenous stimulus|
|locomotion|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|tissue development|
|establishment of localization in cell|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14362
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGA4 Expression in NALM6 Cells: 8.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>