======= ITGA6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGA6
  * **<color #00a2e8>Official Name</color>**: integrin subunit alpha 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3655|3655]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23229|P23229]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGA6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGA6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147556|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Integrin alpha2|
|FG-GAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrin alpha6-beta4 complex|
|neuregulin binding|
|ectodermal cell differentiation|
|hemidesmosome|
|nail development|
|insulin-like growth factor I binding|
|hemidesmosome assembly|
|filopodium assembly|
|ectoderm development|
|amelogenesis|
|laminin binding|
|brown fat cell differentiation|
|basal plasma membrane|
|cell-substrate junction assembly|
|filopodium|
|odontogenesis of dentin-containing tooth|
|basement membrane|
|integrin-mediated signaling pathway|
|negative regulation of extrinsic apoptotic signaling pathway|
|cell-cell adherens junction|
|fat cell differentiation|
|odontogenesis|
|positive regulation of cell-substrate adhesion|
|cell-matrix adhesion|
|digestive tract development|
|digestive system development|
|regulation of extrinsic apoptotic signaling pathway|
|cell junction assembly|
|appendage development|
|limb development|
|cell-substrate adhesion|
|regulation of cell-substrate adhesion|
|cell junction organization|
|negative regulation of apoptotic signaling pathway|
|positive regulation of cell-cell adhesion|
|cellular response to extracellular stimulus|
|protein-containing complex binding|
|positive regulation of neuron projection development|
|renal system development|
|cadherin binding|
|urogenital system development|
|cellular response to external stimulus|
|extracellular matrix organization|
|positive regulation of neuron differentiation|
|leukocyte migration|
|positive regulation of cell projection organization|
|skin development|
|extracellular structure organization|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|positive regulation of cell adhesion|
|positive regulation of GTPase activity|
|focal adhesion|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|positive regulation of neurogenesis|
|regulation of GTPase activity|
|regulation of neuron projection development|
|positive regulation of cell migration|
|cell-cell adhesion|
|positive regulation of cell motility|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|positive regulation of locomotion|
|cell surface|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of cell projection organization|
|positive regulation of hydrolase activity|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|response to organic cyclic compound|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12655
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGA6 Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>