======= ITGA8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGA8
  * **<color #00a2e8>Official Name</color>**: integrin subunit alpha 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8516|8516]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53708|P53708]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGA8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGA8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604063|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. {ECO:0000269|PubMed:12415008, ECO:0000269|PubMed:15721307}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FG-GAP|
|Integrin alpha2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrin alpha8-beta1 complex|
|positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|
|dendritic spine membrane|
|smooth muscle tissue development|
|integrin complex|
|mesodermal cell differentiation|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|smooth muscle cell differentiation|
|substrate adhesion-dependent cell spreading|
|mesoderm formation|
|mesoderm morphogenesis|
|apical part of cell|
|metanephros development|
|integrin-mediated signaling pathway|
|inner ear morphogenesis|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|formation of primary germ layer|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|memory|
|ear morphogenesis|
|mesoderm development|
|cell-matrix adhesion|
|perikaryon|
|gastrulation|
|cell-substrate adhesion|
|inner ear development|
|ear development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|muscle cell differentiation|
|postsynaptic density|
|sensory organ morphogenesis|
|learning or memory|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|renal system development|
|embryonic organ morphogenesis|
|muscle tissue development|
|cognition|
|urogenital system development|
|extracellular matrix organization|
|extracellular structure organization|
|focal adhesion|
|embryonic organ development|
|muscle structure development|
|cell-cell adhesion|
|sensory organ development|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|behavior|
|cell surface|
|cell morphogenesis|
|brain development|
|head development|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|endoplasmic reticulum|
|cell projection organization|
|positive regulation of transcription by RNA polymerase II|
|nervous system process|
|positive regulation of transcription, DNA-templated|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3007
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGA8 Expression in NALM6 Cells: 0.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>