======= ITGB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGB2
  * **<color #00a2e8>Official Name</color>**: integrin subunit beta 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3689|3689]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05107|P05107]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600065|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). {ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:28807980}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Integrin beta|
|Integrin b cyt|
|Integrin B tail|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic region|
|integrin alphaL-beta2 complex|
|integrin alphaM-beta2 complex|
|ICAM-3 receptor activity|
|positive regulation of prostaglandin-E synthase activity|
|regulation of prostaglandin-E synthase activity|
|negative regulation of catecholamine metabolic process|
|positive regulation of neutrophil activation|
|positive regulation of neutrophil degranulation|
|negative regulation of dopamine metabolic process|
|complement component C3b binding|
|negative regulation of cellular amine metabolic process|
|regulation of neutrophil degranulation|
|positive regulation of isomerase activity|
|regulation of isomerase activity|
|regulation of neutrophil activation|
|positive regulation of leukocyte adhesion to vascular endothelial cell|
|leukocyte migration involved in inflammatory response|
|cargo receptor activity|
|cellular response to low-density lipoprotein particle stimulus|
|toll-like receptor 4 signaling pathway|
|positive regulation of superoxide anion generation|
|regulation of leukocyte adhesion to vascular endothelial cell|
|regulation of dopamine metabolic process|
|regulation of catecholamine metabolic process|
|amyloid-beta clearance|
|regulation of superoxide anion generation|
|cell adhesion mediated by integrin|
|positive regulation of leukocyte degranulation|
|integrin complex|
|response to lipoprotein particle|
|cellular response to lipoprotein particle stimulus|
|leukocyte activation involved in inflammatory response|
|plasma membrane raft|
|microglial cell activation|
|positive regulation of protein targeting to membrane|
|positive regulation of myeloid leukocyte mediated immunity|
|regulation of superoxide metabolic process|
|heterotypic cell-cell adhesion|
|regulation of protein targeting to membrane|
|glial cell activation|
|positive regulation of nitric oxide biosynthetic process|
|cellular extravasation|
|positive regulation of nitric oxide metabolic process|
|endodermal cell differentiation|
|neuroinflammatory response|
|receptor clustering|
|endoderm formation|
|regulation of leukocyte degranulation|
|macrophage activation|
|positive regulation of reactive oxygen species biosynthetic process|
|leukocyte cell-cell adhesion|
|positive regulation of regulated secretory pathway|
|extracellular vesicle|
|regulation of nitric oxide biosynthetic process|
|natural killer cell activation|
|regulation of myeloid leukocyte mediated immunity|
|heat shock protein binding|
|cell adhesion molecule binding|
|ficolin-1-rich granule membrane|
|receptor internalization|
|endothelial cell migration|
|endoderm development|
|tertiary granule membrane|
|regulation of cellular amine metabolic process|
|amyloid-beta binding|
|neutrophil chemotaxis|
|regulation of protein targeting|
|epithelial cell migration|
|localization within membrane|
|regulation of reactive oxygen species biosynthetic process|
|epithelium migration|
|granulocyte chemotaxis|
|positive regulation of exocytosis|
|neutrophil migration|
|specific granule membrane|
|positive regulation of neuron death|
|tissue migration|
|integrin-mediated signaling pathway|
|positive regulation of reactive oxygen species metabolic process|
|toll-like receptor signaling pathway|
|granulocyte migration|
|receptor metabolic process|
|formation of primary germ layer|
|positive regulation of protein localization to membrane|
|cell-matrix adhesion|
|pattern recognition receptor signaling pathway|
|myeloid leukocyte migration|
|phagocytosis, engulfment|
|integrin binding|
|positive regulation of leukocyte mediated immunity|
|plasma membrane invagination|
|membrane invagination|
|leukocyte chemotaxis|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of cell shape|
|positive regulation of intracellular protein transport|
|gastrulation|
|regulation of regulated secretory pathway|
|positive regulation of angiogenesis|
|ameboidal-type cell migration|
|regulation of reactive oxygen species metabolic process|
|positive regulation of vasculature development|
|cell-substrate adhesion|
|regulation of protein localization to membrane|
|receptor complex|
|regulation of leukocyte mediated immunity|
|positive regulation of intracellular transport|
|cell chemotaxis|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of exocytosis|
|regulation of intracellular protein transport|
|innate immune response-activating signal transduction|
|receptor-mediated endocytosis|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|activation of innate immune response|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|positive regulation of DNA-binding transcription factor activity|
|aging|
|regulation of angiogenesis|
|regulation of leukocyte cell-cell adhesion|
|regulation of neuron death|
|regulation of vasculature development|
|positive regulation of cellular protein localization|
|phagocytosis|
|extracellular matrix organization|
|positive regulation of innate immune response|
|regulation of intracellular transport|
|regulation of neurotransmitter levels|
|positive regulation of response to biotic stimulus|
|leukocyte migration|
|lymphocyte activation|
|extracellular structure organization|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|focal adhesion|
|positive regulation of cell activation|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of immune effector process|
|positive regulation of defense response|
|protein localization to membrane|
|neutrophil degranulation|
|protein heterodimerization activity|
|regulation of cell morphogenesis|
|neutrophil activation involved in immune response|
|inflammatory response|
|neutrophil mediated immunity|
|neutrophil activation|
|cell-cell adhesion|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|endocytosis|
|immune response-activating signal transduction|
|embryonic morphogenesis|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|protein-containing complex|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|import into cell|
|regulation of cell adhesion|
|positive regulation of cell death|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|exocytosis|
|regulation of secretion|
|membrane organization|
|positive regulation of immune response|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|apoptotic process|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|cell migration|
|embryo development|
|positive regulation of transport|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|locomotion|
|defense response|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|movement of cell or subcellular component|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8762
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGB2 Expression in NALM6 Cells: 7.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>