======= ITGB4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGB4
  * **<color #00a2e8>Official Name</color>**: integrin subunit beta 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3691|3691]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16144|P16144]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGB4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGB4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147557|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Integrin beta|
|Calx-beta|
|fn3|
|Integrin B tail|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuregulin binding|
|hemidesmosome|
|nail development|
|insulin-like growth factor I binding|
|hemidesmosome assembly|
|amelogenesis|
|cell adhesion mediated by integrin|
|integrin complex|
|mesodermal cell differentiation|
|cell leading edge|
|cell-substrate junction assembly|
|G protein-coupled receptor binding|
|mesoderm formation|
|mesoderm morphogenesis|
|odontogenesis of dentin-containing tooth|
|integrin-mediated signaling pathway|
|formation of primary germ layer|
|odontogenesis|
|mesoderm development|
|cell-matrix adhesion|
|digestive tract development|
|integrin binding|
|digestive system development|
|gastrulation|
|cell junction assembly|
|appendage development|
|limb development|
|cell-substrate adhesion|
|receptor complex|
|cell junction organization|
|autophagy|
|process utilizing autophagic mechanism|
|renal system development|
|urogenital system development|
|extracellular matrix organization|
|skin development|
|extracellular structure organization|
|focal adhesion|
|cell junction|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|cell surface|
|tube development|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|embryo development|
|localization of cell|
|cell motility|
|locomotion|
|movement of cell or subcellular component|
|tissue development|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.76|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6020
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGB4 Expression in NALM6 Cells: -0.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>