======= ITGB8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGB8
  * **<color #00a2e8>Official Name</color>**: integrin subunit beta 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3696|3696]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26012|P26012]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGB8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGB8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604160|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Integrin alpha-V/beta-8 is a receptor for fibronectin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Integrin beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrin alphav-beta8 complex|
|extracellular matrix protein binding|
|regulation of transforming growth factor beta activation|
|ganglioside metabolic process|
|cell adhesion mediated by integrin|
|integrin complex|
|placenta blood vessel development|
|regulation of transforming growth factor beta production|
|glycosphingolipid metabolic process|
|vasculogenesis|
|ceramide metabolic process|
|integrin-mediated signaling pathway|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|cell-matrix adhesion|
|integrin binding|
|placenta development|
|sphingolipid metabolic process|
|positive regulation of angiogenesis|
|cartilage development|
|positive regulation of vasculature development|
|cell-substrate adhesion|
|membrane lipid metabolic process|
|signaling receptor activity|
|connective tissue development|
|regulation of angiogenesis|
|regulation of vasculature development|
|extracellular matrix organization|
|extracellular structure organization|
|blood vessel morphogenesis|
|focal adhesion|
|reproductive structure development|
|reproductive system development|
|blood vessel development|
|skeletal system development|
|vasculature development|
|cardiovascular system development|
|cell surface|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of cytokine production|
|cellular amide metabolic process|
|tube development|
|circulatory system development|
|cell adhesion|
|biological adhesion|
|cellular lipid metabolic process|
|cell migration|
|carbohydrate derivative metabolic process|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|lipid metabolic process|
|locomotion|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.92|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.88|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.74|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.71|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.71|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.78|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.87|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.04|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.58|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.63|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.71|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|4.14|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|4.25|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|4.67|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.431|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15656
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGB8 Expression in NALM6 Cells: 3.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>