======= ITPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITPA
  * **<color #00a2e8>Official Name</color>**: inosine triphosphatase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3704|3704]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BY32|Q9BY32]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147520|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:17090528}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ham1p like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ITP catabolic process|
|purine ribonucleoside triphosphate catabolic process|
|ribonucleoside triphosphate catabolic process|
|dITP diphosphatase activity|
|ITP metabolic process|
|purine nucleoside triphosphate catabolic process|
|nucleoside-triphosphate diphosphatase activity|
|NADH pyrophosphatase activity|
|deoxyribonucleoside triphosphate catabolic process|
|nucleoside triphosphate catabolic process|
|deoxyribonucleoside triphosphate metabolic process|
|purine ribonucleotide catabolic process|
|ribonucleotide catabolic process|
|purine nucleotide catabolic process|
|purine-containing compound catabolic process|
|purine ribonucleoside triphosphate metabolic process|
|nucleotide binding|
|nucleotide catabolic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|nucleoside phosphate catabolic process|
|nucleoside triphosphate metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|organophosphate catabolic process|
|carbohydrate derivative catabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-3.04|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.62|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.54|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.01|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.99|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.96|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.76|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.73|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.7|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.02|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rnaseh2b|RNASEH2B]]|0.484|
|[[:human genes:e:elp2|ELP2]]|0.443|
|[[:human genes:e:eif1ax|EIF1AX]]|0.412|
|[[:human genes:u:urm1|URM1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10676
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITPA Expression in NALM6 Cells: 5.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>