======= ITPKB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITPKB
  * **<color #00a2e8>Official Name</color>**: inositol-trisphosphate 3-kinase B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3707|3707]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P27987|P27987]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITPKB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITPKB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147522|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IPK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of neutrophil apoptotic process|
|inositol-1,4,5-trisphosphate 3-kinase activity|
|regulation of neutrophil apoptotic process|
|common myeloid progenitor cell proliferation|
|positive thymic T cell selection|
|negative regulation of myeloid cell apoptotic process|
|inositol trisphosphate metabolic process|
|thymic T cell selection|
|positive T cell selection|
|inositol phosphate biosynthetic process|
|regulation of myeloid cell apoptotic process|
|T cell selection|
|positive regulation of alpha-beta T cell differentiation|
|negative regulation of leukocyte apoptotic process|
|T cell differentiation in thymus|
|inositol phosphate metabolic process|
|polyol biosynthetic process|
|positive regulation of alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|positive regulation of Ras protein signal transduction|
|positive regulation of small GTPase mediated signal transduction|
|negative regulation of myeloid cell differentiation|
|regulation of leukocyte apoptotic process|
|positive regulation of T cell differentiation|
|cellular response to calcium ion|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|myeloid cell homeostasis|
|polyol metabolic process|
|alcohol biosynthetic process|
|T cell differentiation|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|positive regulation of leukocyte differentiation|
|response to calcium ion|
|regulation of lymphocyte differentiation|
|organic hydroxy compound biosynthetic process|
|positive regulation of hemopoiesis|
|cellular response to metal ion|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|calmodulin binding|
|positive regulation of leukocyte cell-cell adhesion|
|cellular response to inorganic substance|
|regulation of myeloid cell differentiation|
|T cell activation|
|lymphocyte differentiation|
|regulation of Ras protein signal transduction|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|regulation of leukocyte cell-cell adhesion|
|alcohol metabolic process|
|regulation of T cell activation|
|leukocyte differentiation|
|regulation of small GTPase mediated signal transduction|
|positive regulation of lymphocyte activation|
|response to metal ion|
|MAPK cascade|
|lymphocyte activation|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|organic hydroxy compound metabolic process|
|regulation of lymphocyte activation|
|response to inorganic substance|
|organophosphate biosynthetic process|
|cell population proliferation|
|hemopoiesis|
|small molecule biosynthetic process|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|regulation of cell adhesion|
|negative regulation of cell differentiation|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|leukocyte activation|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|negative regulation of cell death|
|positive regulation of intracellular signal transduction|
|cell activation|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|phosphorylation|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.26|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.09|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.88|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.75|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.71|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.7|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.74|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15967
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITPKB Expression in NALM6 Cells: 5.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>