======= JAK3 =======
== Gene Information ==
* **Official Symbol**: JAK3
* **Official Name**: Janus kinase 3
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3718|3718]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P52333|P52333]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=JAK3&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20JAK3|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/600173|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008].
* **UniProt Summary**: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:20440074, ECO:0000269|PubMed:7662955, ECO:0000269|PubMed:8022485}.
|Pkinase|
|Pkinase Tyr|
|regulation of FasL biosynthetic process|
|negative regulation of FasL biosynthetic process|
|negative regulation of dendritic cell cytokine production|
|negative regulation of T-helper 1 cell differentiation|
|interleukin-4-mediated signaling pathway|
|negative regulation of thymocyte apoptotic process|
|negative regulation of T-helper 1 type immune response|
|response to interleukin-21|
|interleukin-21-mediated signaling pathway|
|cellular response to interleukin-21|
|tyrosine phosphorylation of STAT protein|
|interleukin-9-mediated signaling pathway|
|cellular response to interleukin-9|
|response to interleukin-9|
|regulation of T-helper 1 cell differentiation|
|interleukin-2-mediated signaling pathway|
|regulation of dendritic cell cytokine production|
|cellular response to interleukin-2|
|regulation of thymocyte apoptotic process|
|negative regulation of glycoprotein biosynthetic process|
|cellular response to interleukin-15|
|response to interleukin-2|
|interleukin-15-mediated signaling pathway|
|growth hormone receptor signaling pathway via JAK-STAT|
|response to interleukin-15|
|negative regulation of T-helper cell differentiation|
|negative regulation of interleukin-12 production|
|negative regulation of glycoprotein metabolic process|
|negative regulation of interleukin-10 production|
|negative regulation of T cell apoptotic process|
|interleukin-7-mediated signaling pathway|
|growth hormone receptor signaling pathway|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|cellular response to growth hormone stimulus|
|negative regulation of alpha-beta T cell differentiation|
|negative regulation of cytokine production involved in immune response|
|regulation of T-helper 1 type immune response|
|negative regulation of lymphocyte apoptotic process|
|response to interleukin-7|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|cellular response to interleukin-4|
|cellular response to interleukin-7|
|response to interleukin-4|
|T cell homeostasis|
|regulation of T cell apoptotic process|
|regulation of T-helper cell differentiation|
|response to growth hormone|
|negative regulation of production of molecular mediator of immune response|
|negative regulation of alpha-beta T cell activation|
|receptor signaling pathway via JAK-STAT|
|receptor signaling pathway via STAT|
|regulation of glycoprotein biosynthetic process|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of T cell differentiation|
|regulation of glycoprotein metabolic process|
|negative regulation of adaptive immune response|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|negative regulation of leukocyte apoptotic process|
|non-membrane spanning protein tyrosine kinase activity|
|negative regulation of leukocyte mediated immunity|
|regulation of lymphocyte apoptotic process|
|regulation of interleukin-10 production|
|negative regulation of lymphocyte differentiation|
|lymphocyte homeostasis|
|regulation of interleukin-12 production|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|leukocyte homeostasis|
|erythrocyte differentiation|
|regulation of leukocyte apoptotic process|
|regulation of cytokine production involved in immune response|
|protein phosphatase binding|
|protein tyrosine kinase activity|
|erythrocyte homeostasis|
|regulation of alpha-beta T cell activation|
|positive regulation of T cell proliferation|
|negative regulation of leukocyte differentiation|
|myeloid cell homeostasis|
|B cell differentiation|
|negative regulation of T cell activation|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of lymphocyte proliferation|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of mononuclear cell proliferation|
|regulation of receptor signaling pathway via STAT|
|negative regulation of hemopoiesis|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|regulation of production of molecular mediator of immune response|
|peptidyl-tyrosine phosphorylation|
|negative regulation of lymphocyte activation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|peptidyl-tyrosine modification|
|negative regulation of immune response|
|B cell activation|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|regulation of lymphocyte differentiation|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|negative regulation of cell activation|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|myeloid cell differentiation|
|regulation of leukocyte proliferation|
|lymphocyte differentiation|
|positive regulation of cell-cell adhesion|
|cellular response to peptide hormone stimulus|
|endosome|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|cellular response to peptide|
|leukocyte differentiation|
|positive regulation of lymphocyte activation|
|cytoskeleton|
|MAPK cascade|
|lymphocyte activation|
|response to peptide hormone|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|regulation of immune effector process|
|response to peptide|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|hemopoiesis|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|regulation of cell activation|
|immune system development|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cytokine production|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|innate immune response|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|leukocyte activation|
|negative regulation of developmental process|
|defense response to other organism|
|protein phosphorylation|
|negative regulation of cell death|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|response to cytokine|
|negative regulation of protein metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|regulation of cell differentiation|
|immune response|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.74|
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 9020
* **Expression level (log2 read counts)**: 5.99
{{:chemogenomics:nalm6 dist.png?nolink |}}