======= KATNA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KATNA1
  * **<color #00a2e8>Official Name</color>**: katanin catalytic subunit A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11104|11104]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75449|O75449]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KATNA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KATNA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606696|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA|
|Vps4 C|
|RuvB N|
|AAA 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule-severing ATPase activity|
|microtubule severing|
|isomerase activity|
|mitotic spindle pole|
|cytoplasmic microtubule organization|
|spindle|
|spindle pole|
|midbody|
|ATPase activity|
|microtubule binding|
|microtubule|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|protein heterodimerization activity|
|centrosome|
|cell division|
|microtubule-based process|
|cytoskeleton organization|
|cell cycle|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-4.75|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-4.54|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-3.57|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-3.55|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-3.12|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-3.01|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-3|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.59|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.55|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.24|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.89|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.76|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.8|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:katnb1|KATNB1]]|0.572|
|[[:human genes:w:wdr62|WDR62]]|0.513|
|[[:human genes:k:kif2a|KIF2A]]|0.484|
|[[:human genes:t:ttl|TTL]]|0.437|
|[[:human genes:w:wbp4|WBP4]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15968
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KATNA1 Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>