======= KCNB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNB1
  * **<color #00a2e8>Official Name</color>**: potassium voltage-gated channel subfamily B member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3745|3745]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14721|Q14721]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600397|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:8081723, PubMed:1283219, PubMed:10484328, PubMed:12560340, PubMed:19074135, PubMed:19717558, PubMed:24901643). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:10484328, PubMed:11852086, PubMed:12060745, PubMed:19074135, PubMed:19717558, PubMed:24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage- gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed:12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose- induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity). {ECO:0000250|UniProtKB:P15387, ECO:0000250|UniProtKB:Q03717, ECO:0000269|PubMed:10484328, ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:12560340, ECO:0000269|PubMed:1283219, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:19717558, ECO:0000269|PubMed:23161216, ECO:0000269|PubMed:24901643, ECO:0000269|PubMed:8081723}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kv2channel|
|Ion trans 2|
|K tetra|
|Ion trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of norepinephrine secretion|
|regulation of motor neuron apoptotic process|
|positive regulation of long-term synaptic depression|
|positive regulation of catecholamine secretion|
|regulation of long-term synaptic depression|
|regulation of norepinephrine secretion|
|positive regulation of calcium ion-dependent exocytosis|
|neuronal cell body membrane|
|dendrite membrane|
|positive regulation of protein targeting to membrane|
|delayed rectifier potassium channel activity|
|positive regulation of amine transport|
|regulation of protein targeting to membrane|
|negative regulation of insulin secretion|
|vesicle docking involved in exocytosis|
|regulation of calcium ion-dependent exocytosis|
|glutamate receptor signaling pathway|
|negative regulation of peptide hormone secretion|
|regulation of action potential|
|positive regulation of regulated secretory pathway|
|lateral plasma membrane|
|voltage-gated potassium channel activity|
|regulation of catecholamine secretion|
|negative regulation of hormone secretion|
|vesicle docking|
|exocytic process|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|cellular response to carbohydrate stimulus|
|regulation of protein targeting|
|voltage-gated potassium channel complex|
|cellular glucose homeostasis|
|positive regulation of exocytosis|
|regulation of amine transport|
|action potential|
|sarcolemma|
|positive regulation of protein localization to membrane|
|ion channel binding|
|negative regulation of protein secretion|
|perikaryon|
|response to glucose|
|negative regulation of peptide secretion|
|response to hexose|
|response to monosaccharide|
|positive regulation of intracellular protein transport|
|potassium ion transmembrane transport|
|regulation of regulated secretory pathway|
|potassium ion transport|
|organelle localization by membrane tethering|
|response to carbohydrate|
|regulation of insulin secretion|
|membrane docking|
|negative regulation of protein transport|
|protein localization to plasma membrane|
|glucose homeostasis|
|negative regulation of establishment of protein localization|
|carbohydrate homeostasis|
|regulation of protein localization to membrane|
|regulation of synaptic plasticity|
|postsynaptic membrane|
|negative regulation of secretion by cell|
|regulation of neuron apoptotic process|
|positive regulation of intracellular transport|
|regulation of peptide hormone secretion|
|regulation of exocytosis|
|protein localization to cell periphery|
|regulation of intracellular protein transport|
|negative regulation of secretion|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|regulation of hormone secretion|
|axon|
|regulation of neuron death|
|positive regulation of cellular protein localization|
|cellular response to external stimulus|
|protein homooligomerization|
|regulation of intracellular transport|
|monovalent inorganic cation transport|
|positive regulation of secretion by cell|
|dendrite|
|positive regulation of protein transport|
|regulation of membrane potential|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|negative regulation of transport|
|protein heterodimerization activity|
|regulation of peptide secretion|
|response to nutrient levels|
|protein complex oligomerization|
|response to extracellular stimulus|
|regulation of hormone levels|
|regulation of cellular protein localization|
|cell junction|
|regulation of vesicle-mediated transport|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|organelle localization|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|regulation of protein transport|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|cation transport|
|cellular homeostasis|
|regulation of cellular localization|
|ion transmembrane transport|
|positive regulation of transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|secretion|
|transmembrane transport|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|homeostatic process|
|regulation of cell death|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.01|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.89|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.79|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11278
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNB1 Expression in NALM6 Cells: 1.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>