======= KCNE1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNE5
  * **<color #00a2e8>Official Name</color>**: potassium voltage-gated channel subfamily E regulatory subunit 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23630|23630]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJ90|Q9UJ90]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNE1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNE1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300328|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. Variants of this gene are associated with idiopathic ventricular fibrillation and Brugada syndrome. [provided by RefSeq, Nov 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. {ECO:0000269|PubMed:12324418}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of potassium ion export across plasma membrane|
|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization|
|regulation of atrial cardiac muscle cell membrane repolarization|
|regulation of potassium ion export across plasma membrane|
|negative regulation of delayed rectifier potassium channel activity|
|ventricular cardiac muscle cell membrane repolarization|
|negative regulation of voltage-gated potassium channel activity|
|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|
|membrane repolarization during ventricular cardiac muscle cell action potential|
|atrial cardiac muscle cell action potential|
|atrial cardiac muscle cell to AV node cell signaling|
|atrial cardiac muscle cell to AV node cell communication|
|potassium ion export across plasma membrane|
|membrane repolarization during cardiac muscle cell action potential|
|membrane repolarization during action potential|
|regulation of delayed rectifier potassium channel activity|
|cardiac muscle cell membrane repolarization|
|negative regulation of potassium ion transmembrane transporter activity|
|ventricular cardiac muscle cell action potential|
|membrane repolarization|
|regulation of ventricular cardiac muscle cell membrane repolarization|
|negative regulation of potassium ion transmembrane transport|
|regulation of cardiac muscle cell membrane repolarization|
|cell-cell signaling involved in cardiac conduction|
|negative regulation of potassium ion transport|
|delayed rectifier potassium channel activity|
|regulation of membrane repolarization|
|regulation of heart rate by cardiac conduction|
|positive regulation of potassium ion transmembrane transport|
|cardiac muscle cell action potential involved in contraction|
|export across plasma membrane|
|potassium channel regulator activity|
|cardiac muscle cell contraction|
|negative regulation of cation channel activity|
|cell communication involved in cardiac conduction|
|positive regulation of potassium ion transport|
|cardiac muscle cell action potential|
|regulation of potassium ion transmembrane transporter activity|
|voltage-gated potassium channel activity|
|negative regulation of ion transmembrane transporter activity|
|cardiac muscle contraction|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|negative regulation of cation transmembrane transport|
|voltage-gated potassium channel complex|
|heart contraction|
|actin-mediated cell contraction|
|cardiac conduction|
|action potential|
|regulation of potassium ion transport|
|negative regulation of ion transmembrane transport|
|regulation of heart rate|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|negative regulation of transmembrane transport|
|ion channel binding|
|multicellular organismal signaling|
|positive regulation of cation transmembrane transport|
|negative regulation of ion transport|
|positive regulation of ion transmembrane transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|regulation of cation channel activity|
|positive regulation of transmembrane transport|
|regulation of heart contraction|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|muscle system process|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|cation transport|
|ion transmembrane transport|
|positive regulation of transport|
|export from cell|
|cell-cell signaling|
|negative regulation of molecular function|
|transmembrane transport|
|ion transport|
|movement of cell or subcellular component|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18035
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNE1L Expression in NALM6 Cells: -1.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>