======= KCNE3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNE3
  * **<color #00a2e8>Official Name</color>**: potassium voltage-gated channel subfamily E regulatory subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10008|10008]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6H6|Q9Y6H6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNE3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNE3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604433|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship. {ECO:0000250|UniProtKB:Q9JJV7, ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:12954870}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ISK Channel|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of membrane repolarization during cardiac muscle cell action potential|
|negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential|
|negative regulation of cardiac muscle cell contraction|
|negative regulation of ventricular cardiac muscle cell action potential|
|negative regulation of potassium ion export across plasma membrane|
|regulation of membrane repolarization during ventricular cardiac muscle cell action potential|
|regulation of membrane repolarization during cardiac muscle cell action potential|
|negative regulation of cardiac muscle contraction|
|regulation of potassium ion export across plasma membrane|
|negative regulation of striated muscle contraction|
|negative regulation of action potential|
|regulation of membrane repolarization during action potential|
|negative regulation of delayed rectifier potassium channel activity|
|positive regulation of voltage-gated calcium channel activity|
|negative regulation of voltage-gated potassium channel activity|
|membrane repolarization during ventricular cardiac muscle cell action potential|
|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|
|ventricular cardiac muscle cell membrane repolarization|
|regulation of ventricular cardiac muscle cell action potential|
|potassium ion export across plasma membrane|
|regulation of delayed rectifier potassium channel activity|
|cardiac muscle cell membrane repolarization|
|membrane repolarization during cardiac muscle cell action potential|
|membrane repolarization during action potential|
|negative regulation of potassium ion transmembrane transporter activity|
|ventricular cardiac muscle cell action potential|
|membrane repolarization|
|negative regulation of muscle contraction|
|regulation of ventricular cardiac muscle cell membrane repolarization|
|negative regulation of heart contraction|
|negative regulation of potassium ion transmembrane transport|
|regulation of cardiac muscle cell membrane repolarization|
|neuronal cell body membrane|
|regulation of cardiac muscle cell action potential|
|negative regulation of potassium ion transport|
|negative regulation of blood circulation|
|delayed rectifier potassium channel activity|
|regulation of membrane repolarization|
|regulation of voltage-gated calcium channel activity|
|regulation of heart rate by cardiac conduction|
|regulation of cardiac muscle cell contraction|
|cardiac muscle cell action potential involved in contraction|
|positive regulation of calcium ion transmembrane transporter activity|
|export across plasma membrane|
|potassium channel regulator activity|
|cardiac muscle cell contraction|
|regulation of actin filament-based movement|
|negative regulation of cation channel activity|
|regulation of action potential|
|cardiac muscle cell action potential|
|regulation of potassium ion transmembrane transporter activity|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|negative regulation of ion transmembrane transporter activity|
|regulation of cardiac muscle contraction|
|cardiac muscle contraction|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|negative regulation of cation transmembrane transport|
|voltage-gated potassium channel complex|
|heart contraction|
|regulation of calcium ion transmembrane transporter activity|
|actin-mediated cell contraction|
|regulation of striated muscle contraction|
|cardiac conduction|
|action potential|
|regulation of potassium ion transport|
|negative regulation of ion transmembrane transport|
|regulation of heart rate|
|heart process|
|positive regulation of ion transmembrane transporter activity|
|striated muscle contraction|
|actin filament-based movement|
|positive regulation of transporter activity|
|negative regulation of transmembrane transport|
|positive regulation of calcium ion transport|
|ion channel binding|
|perikaryon|
|multicellular organismal signaling|
|positive regulation of cation transmembrane transport|
|vesicle|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|potassium ion transmembrane transport|
|regulation of muscle contraction|
|potassium ion transport|
|regulation of cation channel activity|
|positive regulation of transmembrane transport|
|membrane raft|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of calcium ion transport|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|muscle system process|
|negative regulation of cellular component movement|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|dendrite|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|cation transport|
|ion transmembrane transport|
|positive regulation of transport|
|regulation of cellular component movement|
|export from cell|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|transmembrane transport|
|ion transport|
|movement of cell or subcellular component|
|positive regulation of molecular function|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14085
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNE3 Expression in NALM6 Cells: 2.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>